ArticleJournal of the American Society of Nephrology : JASN2025
Alterations in DNA Methylation, Proteomic, and Metabolomic Profiles in African Ancestry Populations with APOL1 Risk Alleles.
Abstract read
In one paragraph
Article in Journal of the American Society of Nephrology : JASN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Update on APOL1 and chronic kidney diseases in children.Pediatric nephrology (Berlin, Germany) · 2026Review
- APOL1 risk genotypes influence DNA methylation across multiple genomic elements in APOL1-APOL4- MYH9 region in African Americans.Clinical epigenetics · 2026Article
- Disease Burden and Disparities of Care for Kidney Health in the Asian Pacific Region: Summary Report From the Diversity and Equity Committee of APSN.Nephrology (Carlton, Vic.) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors.
Xinruo ZhangDepartment of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-5789-4592
Ashley W ScaddenDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0001-7603-1442
Amarnath MarthiDepartment of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0003-0765-988
Victoria L BuchananDepartment of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-9943-9950
Yishu QuDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0001-5937-3811
Kendra R FerrierDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-8813-6871
Brian D ChenDepartment of Biostatistics, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0009-0008-5590-8637
Mariaelisa GraffDepartment of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-6380-1735
Julian AvilaMetabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.ORCID 0000-0001-9388-3946
Eric BoerwinkleDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas.
Steven BuyskeDepartment of Statistics, School of Arts and Sciences, Rutgers University, Piscataway, New Jersey.ORCID 0000-0001-8539-5416
Clary B ClishMetabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.ORCID 0000-0001-8259-9245
Dan CruzInternal Medicine, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.ORCID 0000-0002-2576-7051
Myriam FornageInstitute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas.
Robert E GerzstenDivision of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.ORCID 0000-0002-6767-7687
Christopher R GignouxDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0001-9728-6567
LaShaunta GloverDepartment of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-7721-8169
Lifang HouDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Anne E JusticeDepartment of Population Health Sciences, Geisinger, Danville, Pennsylvania.ORCID 0000-0002-8903-8712
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington.
Holly KramerDepartments of Public Health Sciences and Medicine, Loyola University Chicago, Maywood, Illinois.ORCID 0000-0002-6374-837
Leslie LangeDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-4220-6766
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0002-8532-5087
Tara MatiseDepartment of Genetics, School of Arts and Sciences, Rutgers University, Piscataway, New Jersey.ORCID 0000-0002-7147-492
Josyf C MychaleckyjCenter for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, Virginia.ORCID 0000-0003-2595-0005
Opeyemi A OlabisiDepartment of Medicine, Nephrology, Duke University, Durham, North Carolina.ORCID 0000-0003-0886-7605
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington.
Laura M RaffieldDepartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-7892-193
Alex P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington.ORCID 0000-0002-1427-4470
Stephen S RichCenter for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, Virginia.ORCID 0000-0003-3872-7793
Jerome I RotterDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California.ORCID 0000-0001-7191-1723
Kent D TaylorDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California.ORCID 0000-0002-2756-4370
Bing YuDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas.ORCID 0000-0003-4818-1077
Yinan ZhengDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0002-2006-7320
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-8903-0366
Amy K MottlUNC Kidney Center, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-4258-1726
Heather M HighlandDepartment of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-3583-8239
Maggie A StanislawskiDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0001-7768-8868
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MPILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MCORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - COORDINATING CENTER (CC)75N92023D00002 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LI, JING · 2023 to 2025
$6.8MPAGE III: Population Architecture using Genomics and EpidemiologyR01HG010297 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI GIGNOUX, CHRISTOPHER R, MATISE, TARA C. · 2019 to 2022
$6.5MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2022 to 2025
$5.1MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2022 to 2025
$5.0MNCATS NIH HHS UL1TR001881NCRR NIH HHS UL1RR025005NHGRI NIH HHS 3U01HG004402-02S1NHGRI NIH HHS 3U54HG003067-13S1NHGRI NIH HHS R01HG010297NHGRI NIH HHS U01HG004402NHLBI NIH HHS 3R01HL-117626-02S1NHLBI NIH HHS 5RC2HL102419NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS 75N92023D00002NHLBI NIH HHS 75N92023D00003NHLBI NIH HHS 75N92023D00004NHLBI NIH HHS 75N92023D00005NHLBI NIH HHS 75N92023D00006NHLBI NIH HHS HHSN268201100037CNHLBI NIH HHS HHSN268201300001I/N01-HC-65233NHLBI NIH HHS HHSN268201300002I/N01-HC-65235NHLBI NIH HHS HHSN268201300003I/N01- HC-65236NHLBI NIH HHS HHSN268201300004I/N01-HC-65234NHLBI NIH HHS HHSN268201300005I/N01-HC-65237NHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS HHSN268201600034INHLBI NIH HHS HHSN268201600038INHLBI NIH HHS HHSN268201800001INHLBI NIH HHS HHSN268201800002INHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800013INHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K01 HL157658NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS N02-HL-64278NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01HL105756NHLBI NIH HHS R01HL-120393NHLBI NIH HHS R01 HL163262NHLBI NIH HHS U01HL-120393NHLBI NIH HHS UL1-TR-000040NHLBI NIH HHS UL1-TR-001079NHLBI NIH HHS UL1-TR-001420NIDDK NIH HHS DK063491NIDDK NIH HHS P30 DK048520NIH HHS HHSN268200625226CNINDS NIH HHS R01NS087541
Abstract
PubMed holds no abstract for this paper.
Indexed as
APOL1gene transcriptionmetabolomics
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.