Evidence map›Paper›PMID 40193105›Full record

ArticleHuman brain mapping2025

TractCloud-FOV: Deep Learning-Based Robust Tractography Parcellation in Diffusion MRI With Incomplete Field of View.

Yuqian Chen, Leo Zekelman, Yui Lo, Suheyla Cetin-Karayumak, Tengfei Xue, Yogesh Rathi, Nikos Makris, Fan Zhang, Weidong Cai, Lauren J O'Donnell

Abstract read
In one paragraph

Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Advances in artificial intelligence for neuroimaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuqian ChenHarvard Medical School, Boston, USA.ORCID 0009-0005-5613-2920
Leo ZekelmanBrigham and Women's Hospital, Boston, USA.
Yui LoHarvard Medical School, Boston, USA.ORCID 0009-0004-8713-1886
Suheyla Cetin-KarayumakHarvard Medical School, Boston, USA.
Tengfei XueThe University of Sydney, Sydney, Australia.ORCID 0000-0003-3871-2321
Yogesh RathiHarvard Medical School, Boston, USA.ORCID 0000-0002-9946-2314
Nikos MakrisHarvard Medical School, Boston, USA.
Fan ZhangUniversity of Electronic Science and Technology of China, Chengdu, China.ORCID 0000-0002-5032-6039
Weidong CaiThe University of Sydney, Sydney, Australia.
Lauren J O'DonnellHarvard Medical School, Boston, USA.ORCID 0000-0003-0197-7801

Funding

Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI PUJOL, SONIA · 2012 to 2022
$20.9M
Neural substrates of diffusion imaging in cognitively aging rhesus monkeysR01AG042512 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK, MAKRIS, NIKOLAOS · 2013 to 2023
$6.5M
Next generation in-vivo diffusion imaging at submillimeter resolutionR01MH116173 · NIMH · STANFORD UNIVERSITY · PI Yogesh Rathi, Kawin Setsompop · 2018 to 2026
$6.2M
Mapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRIR01MH125860 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2021 to 2025
$4.1M
High Resolution, Comprehensive Atlases of the Human Brain MorphologyR01MH112748 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI BOUIX, SYLVAIN, KUBICKI, MAREK · 2018 to 2022
$4.1M
Harmonizing multi-site diffusion MRI acquisitions for neuroscientific analysis across ages and brain disordersR01MH119222 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI O'DONNELL, LAUREN JEAN, RATHI, YOGESH · 2019 to 2023
$4.0M
Quantitative Glioblastoma Margin and Infiltration Mapping with Advanced Diffusion-Relaxation MRIR01NS125781 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI ALEXANDRA J GOLBY, Carl-Fredrik Westin · 2022 to 2026
$3.6M
Unraveling the Superficial White Matter of the Primate Brain: Tracer-Based Histology and dMRI Tractography ValidationR01NS125307 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NIKOLAOS MAKRIS, RICHARD Jarrett RUSHMORE · 2022 to 2026
$3.4M
Research Supplement: Naturalistic Neuroimaging for Presurgical Language MappingR01DC020965 · NIDCD · BRIGHAM AND WOMEN'S HOSPITAL · PI Einat Liebenthal, Yanmei Tie · 2023 to 2026
$2.7M
Mapping of the intrinsic and extrinsic cerebellar connectome at ultra high resolution with expert neuroanatomical curationR01MH132610 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2023 to 2025
$2.6M
Mentoring and neuroimaging research on new targets for DBS in OCDK24MH116366 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MAKRIS, NIKOLAOS · 2018 to 2022
$817k
Elucidating the Three-Dimensional Organization of the Human Cerebellar Cortex Using Histological and Ultra-High Resolution Structural MRI ApproachesR21NS136960 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MAKRIS, NIKOLAOS, RUSHMORE, RICHARD JARRETT · 2024 to 2025
$472k
National Key Research and Development Program of China 2023YFE011860National Natural Science Foundation of China 62371107NIA NIH HHS R01 AG042512NIBIB NIH HHS P41 EB015902NIDCD NIH HHS R01 DC020965NIH HHS P41EB015902NIH HHS R01AG042512NIH HHS R01MH112748NIH HHS R01MH116173NIH HHS R01MH119222NIH HHS R01MH125860NIH HHS R01MH132610NIH HHS R01NS125307NIH HHS R01NS125781NIH HHS R21NS136960NIMH NIH HHS K24 MH116366NIMH NIH HHS R01 MH112748NIMH NIH HHS R01 MH116173NIMH NIH HHS R01 MH119222NIMH NIH HHS R01 MH125860NIMH NIH HHS R01 MH132610NINDS NIH HHS R01 NS125307NINDS NIH HHS R01 NS125781NINDS NIH HHS R21 NS136960
6 · The paper itself

Abstract

Tractography parcellation classifies streamlines reconstructed from diffusion MRI into anatomically defined fiber tracts for clinical and research applications. However, clinical scans often have incomplete fields of view (FOV) where brain regions are partially imaged, leading to partial, or truncated fiber tracts. To address this challenge, we introduce TractCloud-FOV, a deep learning framework that robustly parcellates tractography under conditions of incomplete FOV. We propose a novel training strategy, FOV-Cut Augmentation (FOV-CA), in which we synthetically cut tractograms to simulate a spectrum of real-world inferior FOV cutoff scenarios. This data augmentation approach enriches the training set with realistic truncated streamlines, enabling the model to achieve superior generalization. We evaluate the proposed TractCloud-FOV on both synthetically cut tractography and two real-life datasets with incomplete FOV. TractCloud-FOV significantly outperforms several state-of-the-art methods on all testing datasets in terms of streamline classification accuracy, generalization ability, tract anatomical depiction, and computational efficiency. Overall, TractCloud-FOV achieves efficient and consistent tractography parcellation in diffusion MRI with incomplete FOV.

Indexed as

BrainDeep LearningDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingImage Processing, Computer-AssistedWhite MatterAdultHumansdata augmentationdeep learningdiffusion MRIfield of viewtractography parcellation

Identifiers

PMID40193105
PMCPMC11974447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.