Evidence map›Paper›PMID 40193032›Full record

ArticleIndian pediatrics2025

The Implications of Musculoskeletal Manifestations in Acute Lymphoblastic Leukemia: A Decade's Experience from a Referral Center in Southern India.

Konsam Samuel Lyngdoh, Pandya Dhruti, Sidharth Totadri, Somdipa Pal, Jyothi Munireddy, Vandana Bharadwaj, Anand Prakash

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Article in Indian pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Konsam Samuel LyngdohDepartment of Pediatrics, St. John's Medical College and Hospital, Bengaluru, Karnataka, 560034, India.
Pandya DhrutiDepartment of Pediatric Hematology Oncology and Bone Marrow Transplant, St. John's Medical College and Hospital, Bengaluru, Karnataka, 560034, India.
Sidharth TotadriDepartment of Pediatric Hematology Oncology and Bone Marrow Transplant, St. John's Medical College and Hospital, Bengaluru, Karnataka, 560034, India. totadri86@yahoo.com.ORCID 0000-0002-0076-994X
Somdipa PalDepartment of Pediatric Hematology Oncology and Bone Marrow Transplant, St. John's Medical College and Hospital, Bengaluru, Karnataka, 560034, India.
Jyothi MunireddyDepartment of Pediatric Hematology Oncology and Bone Marrow Transplant, St. John's Medical College and Hospital, Bengaluru, Karnataka, 560034, India.
Vandana BharadwajDepartment of Pediatric Hematology Oncology and Bone Marrow Transplant, St. John's Medical College and Hospital, Bengaluru, Karnataka, 560034, India.
Anand PrakashDepartment of Pediatric Hematology Oncology and Bone Marrow Transplant, St. John's Medical College and Hospital, Bengaluru, Karnataka, 560034, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveChildren with acute lymphoblastic leukemia (ALL) with musculoskeletal (MSK) manifestations may be misdiagnosed as juvenile idiopathic arthritis (JIA). The present study compared the baseline parameters and survival outcomes in patients with ALL with and without MSK symptoms.

methodsA retrospective chart review of children aged < 18 years diagnosed with ALL was performed. Based on contemporary parameters, the patients were stratified into standard-risk (SR), intermediate-risk (IR), and high-risk (HR) groups. Clinical and laboratory features and survival outcomes were compared between ALL patients with and without MSK symptoms.

resultsOut of 255 participants, 67 (26%) had MSK manifestations; of these, 9 were pretreated for JIA with glucocorticoids/methotrexate. Patients with MSK manifestations had a longer median duration of symptoms before diagnosis (4 vs 2 weeks, P < 0.001), and a higher median platelet count (53 × 10

conclusionPatients with ALL with MSK manifestations have more preserved blood counts and a longer duration of symptoms before diagnosis. Pretreatment of children with ALL misdiagnosed as JIA with glucocorticoids/methotrexate can delay the diagnosis, confound the risk stratification, and upstage the risk group requiring administration of more toxic chemotherapy than necessary otherwise.

Indexed as

Musculoskeletal DiseasesPrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentArthritis, JuvenileChildChild, PreschoolFemaleHumansIndiaInfantMaleRetrospective StudiesMalignant bone painPediatric cancerRisk stratificationSteroid pretreatmentSystemic onset juvenile idiopathic arthritis

Identifiers

PMID40193032

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