ArticleInternational ophthalmology2025
Predicting the causative agent in microbial keratitis: the role of anterior segment optical coherence tomography-a cross-sectional analysis.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- AS-OCT in infectious keratitis: detecting pachymetry-infiltrate discordance.International ophthalmology · 2026Article
- FilmArray® multiplex PCR panels on corneal swabs in suspected infectious keratitis: a pragmatic real-world study.International ophthalmology · 2026Observational
- Anterior segment optical coherence tomography: imaging characteristics suggestive of microbial etiology in infectious keratitis.International ophthalmology · 2026Article
- Emerging diagnostic modalities in microbial keratitis: Beyond culture and smear.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
- Anterior segment optical coherence tomography: a tool for infectious keratitis.Therapeutic advances in ophthalmologyReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the anterior segment optical coherence tomography (AS-OCT) features of infectious keratitis (IK) and assess their correlation with clinical and microbiological findings.
methodsThis cross-sectional study included 58 patients with culture-positive corneal abscesses, complete medical records, and high-quality AS-OCT imaging. Independent clinical and AS-OCT assessments were conducted to identify pathogen-specific features and evaluate their diagnostic sensitivity.
resultsDistinct AS-OCT patterns were identified for each pathogen. Gram-positive bacterial keratitis was associated with stromal edema (p 0.006; OR = 20.6) and Descemet folds (p 0.01; OR = 4.83), whereas Gram-negative keratitis exhibited diffuse infiltrates (p < 0.001; OR = 14.286) and stromal thinning (p < 0.001; OR = 98.9). Fungal keratitis was characterized by stromal cystic spaces (p < 0.001; OR = 82.1), stromal thinning (p 0.042; OR = 4.71) and endothelial plaques with indistinct corneal boundaries (p < 0.001; OR = 207). Combining AS-OCT with clinical findings enhanced diagnostic sensitivity to 75% for Gram-positive bacterial keratitis, 66.7% for Gram-negative keratitis, and 100% for fungal keratitis.
conclusionsAS-OCT provides key pathogen-specific features in IK, improving diagnostic accuracy, particularly in cases with inconclusive microbiological results. While AS-OCT should not replace microbiological testing, its integration into clinical protocols can refine diagnostic strategies. Future applications of artificial intelligence could further optimize early pathogen identification and treatment outcomes.
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