Evidence map›Paper›PMID 40192960›Full record

ArticleInfection2025

Prevention of varicella-zoster virus infection in early childhood children: effect of 1 versus 2 doses of varicella vaccine on antibody levels.

Dan Wu, Changlei Han, Suting Xiong, Peipei Zhang, Han Gao, Jingyi Jiang, Fengming Wang, Xufeng Lv, Fang Yao, Qinwen Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dan Wu *Changzhou Center for Disease Control and Prevention, Changzhou, China.
Changlei Han *Changzhou Center for Disease Control and Prevention, Changzhou, China.
Suting XiongChangzhou Center for Disease Control and Prevention, Changzhou, China.
Peipei ZhangChangzhou Center for Disease Control and Prevention, Changzhou, China.
Han GaoChangzhou Center for Disease Control and Prevention, Changzhou, China.
Jingyi JiangChangzhou Center for Disease Control and Prevention, Changzhou, China.
Fengming WangChangzhou Center for Disease Control and Prevention, Changzhou, China.
Xufeng LvChangzhou Center for Disease Control and Prevention, Changzhou, China.
Fang YaoChangzhou Center for Disease Control and Prevention, Changzhou, China.
Qinwen XuCenter for Disease Control and Prevention, Zhonglou District, 99 Chahua Road, Changzhou, 213016, China. xqw168@126.com.

Funding

Changzhou Medical young talent scienceand technology project Lcyx2024006Changzhou Science and Technology Foundation CJ20245050Open Research Fund Program of Changzhou Institute for Advanced Study of Public Health, Nanjing Medical University CPHN202301
6 · The paper itself

Abstract

objectiveThis study aimed to ascertain the factors influencing the varicella-zoster virus (VZV) IgG seropositivity and to evaluate the efficacy of varicella vaccination with 1- and 2-dose schedules.

methodsA systematic sampling method was employed to recruit subjects. VZV IgG was calculated using the geometric mean concentration (GMC) and a 95% confidence interval (CI). A multifactorial logistic regression model was employed to calculate the odds ratios (OR) and to identify the influential factors for varicella antibody positivity. A generalized additive model for location, shape and scale (GAMLSS) was employed to compare centile reference values and centile curves of antibody levels for different doses of varicella vaccine (VarV).

results785 individuals were included. The VarV positivity rate was 57.7% for 1 dose and 84.2% for 2 doses. Varicella antibody positivity was significantly associated with VarV doses and time since last vaccination. The GAMLSS model indicated a decline in VZV IgG over time, with the 2-dose group demonstrating superior performance to the 1-dose group across all centile reference values and curves.

conclusionA 2-dose schedule is more effective in improving both VZV IgG seropositivity and GMC than a single dose. The inclusion of the VarV in routine immunization programme should be considered.

Indexed as

Antibodies, ViralChickenpoxChickenpox VaccineHerpesvirus 3, HumanVaricella Zoster Virus InfectionChildChild, PreschoolFemaleHumansImmunization ScheduleImmunoglobulin GInfantMaleVaccinationAntibodies, ViralChickenpox VaccineImmunoglobulin GGAMLSSVaricella vaccinationVaricella-zoster virusVZV IgG antibody

Identifiers

PMID40192960

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.