Evidence map›Paper›PMID 40192959›Full record

ArticleInfection2025

Factors associated with persistent bacteraemia among patients with suspected infective endocarditis.

André Teixeira-Antunes, Virgile Zimmermann, Nicolas Fourré, Nicoleta Ianculescu, Pierre Monney, Georgios Tzimas, Laurence Senn, Piergiorgio Tozzi, Matthias Kirsch, Benoit Guery and 1 more

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In one paragraph

Article in Infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

André Teixeira-AntunesInfectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Virgile ZimmermannInfectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Nicolas FourréInfectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Nicoleta IanculescuDepartment of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Pierre MonneyDepartment of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Georgios TzimasDepartment of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Laurence SennInfectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Piergiorgio TozziDepartment of Cardiac Surgery, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Matthias KirschDepartment of Cardiac Surgery, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Benoit GueryInfectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Matthaios Papadimitriou-OlivgerisInfectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Matthaios.Papadimitriou-Olivgeris@hopitalvs.ch.ORCID https://orcid.org/0000-0003-0565-5105

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo ascertain the predictors of persistent bacteraemia among patients with suspected infective endocarditis (IE) and those with IE.

methodsRetrospective study.

settingThis study conducted at a Swiss university hospital (2015-2023) included adult patients with bacteraemia and suspected IE. Persistent bacteraemia was defined as continued positive blood cultures with the same microorganism for at least 48 h from antibiotic treatment initiation. Endocarditis Team classified cases as IE or not IE.

resultsAmong 2312 episodes of suspected IE, S. aureus was the most common pathogen (1045 episodes; 45%). IE (644; 28%) was the most prevalent infection type. Persistent bacteraemia was observed in 480 (21%) episodes and was independently associated with S. aureus, ≥ 2 positive sets of index blood cultures, resistant bacterium, sepsis, IE, central venous catheter-associated bacteraemia, and acute native bone and joint infections (BJIs), while, streptococcal bacteraemia, appropriate initial antimicrobial treatment and, performance of source control interventions within 48 h were associated with rapid blood culture clearance. Of the 644 IE episodes, persistent bacteraemia was observed in 196 (30%) and was associated with obesity, S. aureus, ≥ 2 positive sets of index blood cultures, resistant bacterium, acute native BJIs, immunologic phenomena, thoracic embolic events, while streptococcal bacteraemia and performance of source control interventions within 48 h were associated with rapid clearance of blood cultures.

conclusionsPersistent bacteraemia was associated with S. aureus and BJI. Delaying source control interventions may increase the risk of persistent bacteraemia. No specific intracardiac lesion was associated with persistent bacteraemia in IE episodes.

Indexed as

BacteremiaEndocarditisEndocarditis, BacterialAdultAgedAged, 80 and overAnti-Bacterial AgentsBlood CultureFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial AgentsBone and joint infectionFollow-up blood culturesInfective endocarditisPersistent bacteraemiaSepsis

Identifiers

PMID40192959
PMCPMC12460498

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.