Evidence map›Paper›PMID 40192944›Full record

Observational studyInternational journal of clinical oncology2025

Investigation of tumor mutation burden using the comprehensive genomic profiling data of vulvar and vaginal malignant tumors: an observational study using C-CAT database.

Manabu Seino, Shiori Sano, Yuta Gonai, Shota Horikawa, Fumihiro Nakamura, Yosuke Okui, Jun Matsukawa, Hirotsugu Sakaki, Norikazu Watanabe, Keiko Yamauchi and 5 more

Abstract readObservational Study
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In one paragraph

Observational study in International journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Manabu SeinoDepartment of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan. m-seino@med.id.yamagata-u.ac.jp.ORCID http://orcid.org/0000-0002-7511-5190
Shiori SanoDepartment of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.
Yuta GonaiDepartment of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.
Shota HorikawaDepartment of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.
Fumihiro NakamuraDepartment of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.
Yosuke OkuiDepartment of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.
Jun MatsukawaDepartment of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.
Hirotsugu SakakiDepartment of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.
Norikazu WatanabeDepartment of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.
Keiko YamauchiDepartment of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.
Tsuyoshi OhtaDepartment of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.
Yuki HoshiGenetic Counseling Unit, Yamagata University Hospital, Yamagata, Japan.
Shuhei SuzukiDepartment of Clinical Oncology, Yamagata Prefecture Shinjo Hospital, Yamagata, Japan.
Masaaki KawaiDepartment of Surgery I, Yamagata University Faculty of Medicine, Yamagata, Japan.
Satoru NagaseDepartment of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to reveal the gene alteration and tumor mutation burden (TMB) statuses of vulvar and vaginal malignant tumors in Japan.

methodsWe investigated the cancer genomic profiling (CGP) data of 79 patients with vulvar and vaginal cancers. These data were obtained from the Center for Cancer Genomics and Advanced Therapeutics (C-CAT).

resultsNone of the patients had high microsatellite instability. Although 21.9% of the patients with vulvar and vaginal squamous cell carcinoma (SCC) had high TMB, those with other histological types did not. The top single-nucleotide variants (SNVs) in SCC were TERT, TP53, CDKN2A, KMT2D, and NOTCH1. The frequencies of ATRX and PBRM1 were significantly higher in TMB-high SCC than in non-TMB-high SCC.

conclusionSCC of the vulva and vagina is expected to have high TMB, and gene alteration status differed between TMB-high and non-TMB-high groups.

Indexed as

Biomarkers, TumorCarcinoma, Squamous CellMutationVaginal NeoplasmsVulvar NeoplasmsAdultAgedAged, 80 and overDatabases, GeneticFemaleGenomicsHumansJapanMiddle AgedPolymorphism, Single NucleotideBiomarkers, TumorCancer genomic profilingTumor mutation burdenVaginal cancerVulvar cancer

Identifiers

PMID40192944

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.