Evidence map›Paper›PMID 40192941›Full record

ArticleCellular oncology (Dordrecht, Netherlands)2025

Tumor-specific CXCR6 positive precursor CD8

Yang Song, Ji Chen, Yaqin Zhang, Ning Wu, Yongjun Zhu, Gang Chen, Feng Miao, Zhiming Chen, Yiqing Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular oncology (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yang Song *Department of Cardio-Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Ji Chen *Department of Cardio-Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Yaqin Zhang *Department of Cardio-Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Ning WuDepartment of Cardio-Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Yongjun ZhuDepartment of Cardio-Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Gang ChenDepartment of Cardio-Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Feng MiaoDepartment of Cardio-Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Zhiming ChenDepartment of Cardio-Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China. chzm_md@163.com.ORCID http://orcid.org/0000-0001-8308-5270
Yiqing WangDepartment of Cardio-Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China. wangyiqing@huashan.org.cn.ORCID http://orcid.org/0000-0003-0873-2831

Funding

National Natural Science Foundation of China 81772042Science Foundation of Shanghai Health Commission 20204Y0484
6 · The paper itself

Abstract

backgroundAdoptive cell therapy (ACT) mediates durable and complete regression of various cancers. However, its efficacy is limited by the long-term persistence of cytotoxic T lymphocytes, given their irreversible dysfunction within the tumor microenvironment. Herein, we aimed to establish an artificial lung metastasis model to examine T-lymphocyte subsets, in order to identify potential effective cell subsets for ACT.

methodsA metastatic lung melanoma mouse model was established using OVA-expressing melanoma B16 cells. Flow cytometry analysis was conducted to examine the surface markers, transcription factors, and secreted cytokines of tumor-specific CD8

resultsExhausted CD8

conclusionsIn our study, a subset of antigen-specific CXCR6-expressing Texp cells was observed within the metastatic tissue. The cells served as a crucial source of effector-like Tex cells and exerted direct cytotoxic effects on tumor cells. Adoptive transfer of CXCR6

Indexed as

CD8-Positive T-LymphocytesLung NeoplasmsMelanoma, ExperimentalReceptors, CXCR6AnimalsCell Line, TumorImmunotherapy, AdoptiveMiceMice, Inbred C57BLNeoplasm MetastasisTumor MicroenvironmentCxcr6 protein, mouseReceptors, CXCR6CXCR6+precursor exhausted T cellImmunotherapyMetastasisTumor-specific

Identifiers

PMID40192941
PMCPMC12119687

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.