ArticleJournal of fluorescence2025
Dual-Quenching Mechanism-Based Fluorometric Sensing Platform for Precise D-Penicillamine Quantification in Therapeutic Drug Monitoring.
Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The trial behind it
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Who cites it
1 citing paper in PubMed.
- Fluorescence quenching-based methods for pharmaceutical analysis: a comprehensive review of principles, probes, and applications.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Review
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Authors and funding
5 authors.
Funding
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Abstract
A novel, highly sensitive fluorometric method for D-penicillamine (D-PA) detection has been developed, addressing critical needs in therapeutic drug monitoring. D-PA, a crucial chelating agent used in treating Wilson's disease, rheumatoid arthritis, and heavy metal poisoning, requires precise quantification due to its narrow therapeutic window and potential toxicity. The proposed method introduces an innovative sensing platform utilizing red-emissive carbon dots (R@CDs) and cobalt ions, which enables exceptional analytical performance through a sophisticated dual-quenching mechanism. The detection strategy involves cobalt ions initially enhancing the fluorescence of R@CDs. Upon D-PA addition, two synergistic quenching effects occur: competitive displacement of cobalt ions from the carbon dot surface and formation of a yellow-colored D-PA-cobalt complex, inducing an inner filter effect. Comprehensive characterization and mechanistic investigation revealed the intricate molecular interactions governing this detection process. The developed method demonstrated excellent analytical performance, exhibiting excellent linearity (R
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Registered trials
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