ArticleJournal of clinical monitoring and computing2025
Detection of fluid responsiveness by changes of perfusion index and pleth-variability index during passive leg raising in spontaneously breathing post-surgical patients: a prospective interventional study.
Article in Journal of clinical monitoring and computing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Pre-anesthesia PVI for post-induction hypotension: a robust predictor or a random signal? Comments on Ollaek et al.Journal of anesthesia · 2026Article
- Variation of perfusion index to evaluate fluid responsiveness during the preload challenge tests: a systematic review and meta-analysis.Annals of intensive care · 2026Article
- The predictive value of perfusion indices in the triage and clinical management of carbon monoxide poisoning.Journal of clinical monitoring and computing · 2025Observational
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Predicting fluid responsiveness is crucial in treating circulatory failure, as only about half of patients benefit from volume expansion by increasing cardiac output (CO). Dynamic tests like passive leg raising (PLR) are preferred over static parameters. While PLR reliably predicts fluid responsiveness, it typically requires invasive measurement of stroke volume (SV) or CO. The perfusion index (PI) and pleth variability index (PVI) are non-invasive metrics derived from oxygen saturation signals. PI has been shown to correlate with SV, and PVI has predicted fluid responsiveness in mechanically ventilated patients, but their role in spontaneously breathing patients remains unclear. This study aimed to assess whether PI and PVI could predict fluid responsiveness in post-surgical, spontaneously breathing patients during a PLR test. The hypothesis was that PI would increase and PVI would decrease in fluid responders. The prospective study included spontaneously breathing patients after major abdominal surgery in the ICU of Merano Hospital, Italy. SV and CO were measured using the FloTrac™ system, and PI and PVI were assessed using the Radical 7
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