Article3D printing in medicine2025
Custom-made 3D-printed X-ray shield for tumor-specific irradiation of xenograft mice.
Article in 3D printing in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundXenograft mouse models play an important role in preclinical cancer research, particularly in the development of new therapeutics. To test the efficacy of a combination therapy consisting of radiation and new drug candidates, it is crucial that only the tumor area is irradiated, while other parts of the body are shielded. In this study, a 3D-printed radiopaque back shield was designed for tumor-specific irradiation and evaluated in a xenograft mouse model.
methodsDifferent radiopaque materials were initially tested for their shielding properties using the Multirad 225 X-ray irradiator and the most suitable material was used for printing a back shield with a tumor site-specific opening of the cover. Tumor bearing mice were irradiated four times with a dose of 3.5 Gy. To evaluate proper body shielding, blood samples, spleens and bone marrow were examined at the end of the experiment.
resultsA tungsten filament was identified to be most efficient for shielding and used to 3D print a pie-slice-shaped back shield with a tumor-site specific opening, while polylactic acid was used to print a scaffold that ensured proper positioning of the shield. The simple design allowed cost-efficient and fast 3D printing, easy handling and individual modifications of the tumor site openings. In terms of animal safety, the product provided sufficient shielding in the low-dose irradiation protocols of xenograft mice.
conclusionThe custom-designed 3D-printed tungsten back shields provide proper shielding of the animals body and allow for subcutaneous tumor irradiation under standardized conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.