Evidence map›Paper›PMID 40192847›Full record

ArticleNeuroradiology2025

Pipeline embolization device in treating middle cerebral artery aneurysms: a single-center experience in 69 consecutive patients.

Haoyu Zhu, Jiarui Zhang, Lian Liu, Chao Ma, Yuzhou Chang, Yuqi Song, Xiguang Fu, Longhui Zhang, Yupeng Zhang, Chuhan Jiang and 1 more

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Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Haoyu Zhu *Department of Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Jiarui Zhang *Department of Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Lian LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Chao MaDepartment of Neurosurgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Yuzhou ChangDepartment of Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Yuqi SongDepartment of Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Xiguang FuDepartment of Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Longhui ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yupeng ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Chuhan JiangDepartment of Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China. jiangchuhan126@126.com.
Shikai LiangDepartment of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China. liangshikai90@126.com.ORCID http://orcid.org/0000-0001-5623-7400

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe pipeline embolization device (PED) has been established as an effective treatment option for aneurysms within its designated indications. Recently, its off-label applications, including treating middle cerebral artery (MCA) aneurysms, have increased. This study augmented the current literature by examining the outcomes of PED utilization for MCA aneurysms.

methodsWe collected data from consecutive patients with MCA aneurysms treated with PED between June 2016 and December 2021. Particularly, we collected data on patient demographics, aneurysm characteristics, procedural details, perioperative complications, and clinical and angiographic follow-up results.

resultsA total of 69 patients (mean age 47.4 years; 42.0% female) with MCA aneurysms who underwent PED treatment were included in this study. Among these, 5 aneurysms had ruptured previously, and 10 patients had previously undergone open surgery or received endovascular treatment. In the last angiographic follow-up, conducted at a mean of 19.0 ± 13.5 months, 44 of 56 (78.6%) aneurysms achieved complete occlusion. Ten (17.9%) and three (5.4%) patients exhibited in-stent stenosis and MCA occlusion, respectively. During a mean clinical follow-up period of 35.1 months, 10 of 63 patients (15.8%) experienced major procedure-related complications, including 2 hemorrhagic (3.2%) and 8 ischemic (12.7%) events.

conclusionPED is a viable treatment for MCA aneurysms, particularly those with fusiform and wide-necked characteristics that pose challenges for traditional open surgery. PED shows favorable clinical outcomes and occlusion rates and presents a notable risk of complications and in-stent restenosis. Therefore, careful patient selection is crucial when using PEDs to treat MCA aneurysms.

Indexed as

Embolization, TherapeuticIntracranial AneurysmAdultAgedCerebral AngiographyFemaleHumansMaleMiddle AgedRetrospective StudiesStentsTreatment OutcomeAneurysmsIn-stent restenosisMiddle cerebral arteryOff-labelPipeline embolization device

Identifiers

PMID40192847

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