Evidence map›Paper›PMID 40192841›Full record

ArticleCellular and molecular life sciences : CMLS2025

Immunogenicity and protective efficacy of an inactivated bivalent vaccine containing two recombinant H1N1 and H3N2 swine influenza virus strains.

Heng Zhang, Xu Chen, Dongying Liu, Xinyu Liu, Yifan Ge, Yani Sun, Xiaoyue Zhang, Guangen Hao, Zhaoyang Li, Qingqing Song and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Heng Zhang *College of Veterinary Medicine, Northwest A&F University, Yangling, Shanxi, 712100, China.ORCID http://orcid.org/0000-0002-3757-6762
Xu Chen *College of Veterinary Medicine, Northwest A&F University, Yangling, Shanxi, 712100, China.
Dongying LiuCollege of Veterinary Medicine, Northwest A&F University, Yangling, Shanxi, 712100, China.
Xinyu LiuCollege of Veterinary Medicine, Northwest A&F University, Yangling, Shanxi, 712100, China.
Yifan GeCollege of Veterinary Medicine, Northwest A&F University, Yangling, Shanxi, 712100, China.
Yani SunCollege of Veterinary Medicine, Northwest A&F University, Yangling, Shanxi, 712100, China.
Xiaoyue ZhangSwine Disease R&D Center, Shandong SINDER Technology Co., Ltd, Qingdao, 266104, China.
Guangen HaoSwine Disease R&D Center, Shandong SINDER Technology Co., Ltd, Qingdao, 266104, China.
Zhaoyang LiSwine Disease R&D Center, Shandong SINDER Technology Co., Ltd, Qingdao, 266104, China.
Qingqing SongSwine Disease R&D Center, Shandong SINDER Technology Co., Ltd, Qingdao, 266104, China.
Lei WangCollege of Veterinary Medicine, Northwest A&F University, Yangling, Shanxi, 712100, China.
Zhao WangSchool of Laboratory Animal & Shandong Laboratory Animal Center, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, China. wangzhao@sdfmu.edu.cn.
Huanliang YangKey Laboratory of Animal Influenza, Ministry of Agriculture and Rural Affairs, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150009, China. yanghuanliang@caas.cn.
Qing PanCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, China. panqing20050101@126.com.
Qin ZhaoCollege of Veterinary Medicine, Northwest A&F University, Yangling, Shanxi, 712100, China. qinzhao_2004@nwsuaf.edu.cn.

Funding

Major Scientific and Technological Innovation Project (MSTIP) grant no.2023CXGC010705Shandong Province Pig Industry Technology System SDAIT-08-17
6 · The paper itself

Abstract

The wild-type H1N1 and H3N2 swine influenza virus (SIV) strains are unsuitable for vaccine production because of high lethality in chicken embryos and low reproductive titers. This study developed recombinant H1N1-Re1 and H3N2-Re1 strains via HA and NA genes from the wild-type H1N1 SW/GX/755/17 and H3N2 SW/GX/1659/17 strains combined with six internal genes from the H1N1 A/PR/8/34 strain. The recombinant viruses demonstrated typical cytopathic effects in MDCK cells, and the presence of viral particles was confirmed via electron microscopy. Growth curve analysis revealed titers of 10

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza VaccinesOrthomyxoviridae InfectionsSwine DiseasesAnimalsAntibodies, ViralDogsImmunogenicity, VaccineMadin Darby Canine Kidney CellsSwineVaccines, InactivatedAntibodies, ViralInfluenza VaccinesVaccines, InactivatedH1N1 subtypeH3N2 subtypeImmune durationProtective efficacySwine influenza virus

Identifiers

PMID40192841
PMCPMC11977079

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.