Evidence map›Paper›PMID 40192834›Full record

Trial reportLasers in medical science2025

Two-step photodynamic therapy for facial acne: a randomized controlled trial of pain reduction with 630 nm red light laser.

Shantao Qiu, Yichen Wang, Junru Lu, Guan Jiang

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shantao QiuDepartment of Dermatology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huai Hai Road, Xuzhou, Jiangsu, 221002, People's Republic of China.
Yichen WangDepartment of Dermatology, Xuzhou Central Hospital, 199 South Jiefang Road, Xuzhou, Jiangsu, 221009, People's Republic of China.
Junru LuDepartment of Dermatology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huai Hai Road, Xuzhou, Jiangsu, 221002, People's Republic of China.
Guan JiangDepartment of Dermatology, The Affiliated Hospital of Xuzhou Medical University, 99 West Huai Hai Road, Xuzhou, Jiangsu, 221002, People's Republic of China. dr.guanjiang@xzhmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although topical 5-aminolevulinic acid photodynamic therapy (5-ALA PDT) is an effective treatment for facial acne, many patients report significant pain during the irradiation phase, compromising adherence. Two-step PDT, which modifies irradiance in two phases, has been proposed to reduce pain without compromising treatment efficacy. In this single-center, assessor-blinded randomized trial, 26 patients with facial acne were allocated to either a two-step PDT group (n = 12) or a conventional PDT group (n = 14). After applying 20% 5-ALA for 2 h, both groups received red light (630 ± 5 nm) to deliver a total fluence of 120 J/cm

Indexed as

Acne VulgarisPhotochemotherapyAdolescentAdultAminolevulinic AcidFemaleHumansMalePain MeasurementPatient SatisfactionPhotosensitizing AgentsRed LightTreatment OutcomeYoung AdultAminolevulinic AcidPhotosensitizing AgentsAcneLocal acid photodynamic therapyPainTwo-step photodynamic therapy

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.