Evidence map›Paper›PMID 40192776›Full record

ArticleInternational journal of legal medicine2025

Evaluation of the ForenSeq® Kintelligence Kit and the FORensic Capture Enrichment Panel for Unidentified and Missing Persons Casework.

Jessica L Watson, Kelly Grisedale, Dennis McNevin, Jodie Ward

Abstract readEvaluation Study
In one paragraph

Article in International journal of legal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jessica L WatsonForensics Command, Australian Federal Police, Canberra, Australia. Jessica.Watson@student.uts.edu.au.ORCID http://orcid.org/0000-0002-4649-3395
Kelly GrisedaleForensics Command, Australian Federal Police, Canberra, Australia.ORCID http://orcid.org/0009-0000-3869-2725
Dennis McNevinNational DNA Program for Unidentified and Missing Persons, Australian Federal Police, Canberra, Australia.ORCID http://orcid.org/0000-0003-1665-3367
Jodie WardNational DNA Program for Unidentified and Missing Persons, Australian Federal Police, Canberra, Australia.ORCID http://orcid.org/0000-0001-9359-9806

Funding

Australian Federal Police Innovation Fund
6 · The paper itself

Abstract

Targeted amplicon sequencing (TAS) employs massively parallel sequencing technology to generate profiles comprised of several thousand single nucleotide polymorphisms (SNPs) to assist in identifying an individual and generating investigative leads. By targeting a range of SNP classes, profiles are able to be analysed to infer biological sex, externally visible characteristics, biogeographical ancestry, paternal lineage and relationships to other individuals. Such leads can be beneficial for human remains identification where antemortem data is not available for comparison. This study evaluated the performance and requirements of two in-house TAS pipelines: the ForenSeq® Kintelligence Kit and the FORensic Capture Enrichment (FORCE) panel. Both TAS pipelines demonstrated suitability for a range of samples typically encountered in missing persons cases, including buccal, bone, tooth and nail samples. There was a high degree of concordance between the TAS genotypes and the majority of the genetic intelligence produced was consistent with the self-declared information provided by DNA donors. This study highlights the requirements for each pipeline to be considered by forensic laboratories seeking to establish a forensic genomics capability for unidentified and missing persons casework.

Indexed as

DNA FingerprintingHigh-Throughput Nucleotide SequencingPolymorphism, Single NucleotideSequence Analysis, DNABone and BonesFemaleForensic GeneticsGenotypeHumansMaleNailsToothKinshipMissing personsSingle nucleotide polymorphismTargeted amplicon sequencingUnidentified human remainsWhole genome sequencing

Identifiers

PMID40192776
PMCPMC12354613

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.