Evidence map›Paper›PMID 40192761›Full record

ArticleInternational urogynecology journal2025

Impact of Type and Duration of Oral Antibiotic Prophylaxis on Urinary-Tract Infection Rate After Botox.

Bayley Clarke, Gabriella Yacovone, JooHee Choi, Joanna Marantidis, Marguerite Furlong, Alexis A Dieter

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In one paragraph

Article in International urogynecology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bayley ClarkeSection of Urogynecology and Reconstructive Pelvic Surgery, Medstar Washington Hospital Center, Georgetown University School of Medicine, 106 Irving St NW, Physicians Office Building South, Suite 405, Washington, DC, 20010, USA. Bayleyclarke21@gmail.com.ORCID 0000-0002-8485-7057
Gabriella YacovoneGeorgetown University School of Medicine, Washington, DC, USA.
JooHee ChoiGeorgetown University School of Medicine, Washington, DC, USA.
Joanna MarantidisDepartment of Urology, Medstar Washington Hospital Center, Georgetown University School of Medicine, Washington, DC, USA.
Marguerite FurlongGeorgetown University School of Medicine, Washington, DC, USA.
Alexis A DieterSection of Urogynecology and Reconstructive Pelvic Surgery, Medstar Washington Hospital Center, Georgetown University School of Medicine, 106 Irving St NW, Physicians Office Building South, Suite 405, Washington, DC, 20010, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and hypothesisUrinary tract infection (UTI) is common after onabotulinumtoxin A intradetrusor injections (BTX) but no evidenced-based recommendations exist to guide prophylactic antibiotic regimen. We sought to compare the effect of different oral antibiotic prophylaxis in women with idiopathic and neurogenic overactive bladder (OAB) undergoing BTX.

methodsThis was a single-center retrospective cohort study of women >18 years old who underwent BTX for OAB between June 2018 and June 2023. Duration and type of antibiotic prophylaxis at time of BTX injection were recorded. Primary outcome was treatment for symptomatic UTI within 30 days.

resultsA total of 1250 procedures were included. UTI rate within 30 days of BTX injection was 10% (n = 125). Duration of antibiotics (1 day, 3 days, 5 days, versus ≥7 days of treatment) did not affect 30-day UTI rate (p = 0.42). When comparing antibiotic type, nitrofurantoin had the lowest UTI rate at 8.7% while trimethoprim/sulfamethoxazole (TMP-SMX) had a rate of 12.3% and "other" had highest at 32.4% (p< 0.01). Retreatment rate for UTI was low at 1.9% and urine cultures showed low resistance rates (1.8%) but TMP-SMX had the highest rate of resistance at 4.6% (p < 0.01). There were no differences in retreatment rate or resistance rate between the different durations of prophylactic antibiotics (p>0.05 for both).

conclusionsThe UTI rate after onabotulinumtoxin A injections was similar regardless of the duration of prophylactic antibiotic use. Nitrofurantoin and TMP-SMX had the lowest 30-day UTI rates. These data provide compelling evidence in support of 1-day prophylactic antibiotic treatment regimens with nitrofurantoin (or TMP-SMX) for women with OAB undergoing BTX injection.

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisBotulinum Toxins, Type AUrinary Bladder, OveractiveUrinary Tract InfectionsAdministration, OralAdultAgedFemaleHumansMiddle AgedNitrofurantoinRetrospective StudiesTime FactorsTrimethoprim, Sulfamethoxazole Drug CombinationUrinary Bladder, NeurogenicAnti-Bacterial AgentsBotulinum Toxins, Type ANitrofurantoinonabotulinum toxin ATrimethoprim, Sulfamethoxazole Drug CombinationAntibioticsBotoxOveractive bladderUrinary tract infection

Identifiers

PMID40192761

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.