Evidence map›Paper›PMID 40192605›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Synthesis of Chiral δ-Aminoboronic Esters by Enantioselective Hydrogenation of 1,2-Azaborines.

Jiangpeng Liu, Yuping Dai, Devon Robinson, Bo Li, Karinne Miqueu, Shih-Yuan Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiangpeng LiuDepartment of Chemistry, Boston College, 2609 Beacon Street, Merkert Chemistry Center, Chestnut Hill, MA, 02467, USA.
Yuping DaiE2S UPPA/CNRS, Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Matériaux IPREM UMR 5254, Université de Pau et des Pays de l'Adour, Pau Cedex 09, 64053, France.
Devon RobinsonDepartment of Chemistry, Boston College, 2609 Beacon Street, Merkert Chemistry Center, Chestnut Hill, MA, 02467, USA.
Bo LiDepartment of Chemistry, Boston College, 2609 Beacon Street, Merkert Chemistry Center, Chestnut Hill, MA, 02467, USA.
Karinne MiqueuE2S UPPA/CNRS, Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Matériaux IPREM UMR 5254, Université de Pau et des Pays de l'Adour, Pau Cedex 09, 64053, France.
Shih-Yuan LiuDepartment of Chemistry, Boston College, 2609 Beacon Street, Merkert Chemistry Center, Chestnut Hill, MA, 02467, USA.

Funding

Expanding the Chemical and Functional Space with Boron-Nitrogen HeterocyclesR35GM153328 · NIGMS · BOSTON COLLEGE · PI Shih-Yuan Liu · 2024 to 2026
$1.3M
CryoProbe-enabled Bruker AVANCE NEO 500 MHz NMR SpectrometerS10OD026910 · OD · BOSTON COLLEGE · PI JAYASUNDERA, THUSITHA · 2021 to 2021
$1000k
Bruker D8 VENTURE DiffractometerS10OD030360 · OD · BOSTON COLLEGE · PI LI, BO · 2022 to 2022
$428k
NIGMS NIH HHS R35 GM153328NIGMS NIH HHS R35GM153328NIH HHS S10 OD026910NIH HHS S10 OD030360
6 · The paper itself

Abstract

We describe herein an iridium-catalyzed highly diastereo- and enantioselective hydrogenation of 1,2-azaborines to access δ-aminoboronic esters of potential biological importance. This method represents the first enantioselective hydrogenation of a boron-containing heteroarene and features diverse substitution patterns and wide scope. The synthetic utility of our method was demonstrated by the synthesis of (-)-phenibut and the formal synthesis of (+)-3-PPP and fluvirucinine A

Indexed as

Aminoboronic esterBoron‐nitrogen heterocycleEnantioselective hydrogenationIridium catalysis

Identifiers

PMID40192605
PMCPMC12146072

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.