ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025
Highly-Selective Electrochemical Decarboxylative Late-Stage Functionalization of Amino Acids.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Modular Access to α-Tertiary Amines: Electrochemical Tandem Di-Functionalization of Olefins With Ammonia Surrogates and Amino Acids.Angewandte Chemie (International ed. in English) · 2026Article
- Electrochemical Synthesis of Building Blocks with a Structure Inspired by Nonsteroidal Anti-Inflammatory Drugs.ACS omega · 2026Article
- Advances in electrochemical peptide synthesis and modification.Nature reviews. Chemistry · 2026Review
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Authors and funding
5 authors.
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Abstract
A unified electrochemical decarboxylative strategy for the site-selective construction of carbon-heteroatom bonds is disclosed herein. The metal- and catalyst-free decarboxylation provides access to the functionalization of C- and N-terminus from the simple amino acid feedstock. A wide variety of primary, secondary, and tertiary acids or alcohols were well tolerated. Late-stage functionalization using α-D-galactopyranose, di-peptide, steroid derivatives, and bio-active drug molecules established the robustness and synthesis potential of our approach.
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Registered trials
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