Evidence map›Paper›PMID 40192485›Full record

ArticleChemMedChem2025

First Phosphonic-Type Inhibitors and Activity-Based Probes Specific to the O'nyong-nyong Virus Capsid Protease.

Karolina Torzyk-Jurowska, Agnieszka Łupicka-Słowik, Renata Grzywa, Yuliya Chykunova, Krzysztof Pyrć, Marcin Sieńczyk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karolina Torzyk-JurowskaDivision of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370, Wroclaw, Poland.ORCID https://orcid.org/0000-0003-3432-2529
Agnieszka Łupicka-SłowikDivision of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370, Wroclaw, Poland.ORCID https://orcid.org/0000-0002-5593-5167
Renata GrzywaDivision of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370, Wroclaw, Poland.ORCID https://orcid.org/0000-0002-4064-2409
Yuliya ChykunovaMalopolska Centre of Biotechnology, Virogenetics Laboratory of Virology, Jagiellonian University, Gronostajowa 7a, 30-387, Krakow, Poland.ORCID https://orcid.org/0000-0002-5358-2847
Krzysztof PyrćMalopolska Centre of Biotechnology, Virogenetics Laboratory of Virology, Jagiellonian University, Gronostajowa 7a, 30-387, Krakow, Poland.ORCID https://orcid.org/0000-0002-3867-7688
Marcin SieńczykDivision of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370, Wroclaw, Poland.ORCID https://orcid.org/0000-0002-5528-5264

Funding

Narodowe Centrum Nauki 2018/29/B/NZ6/02622National Science Centre (NCN) of Poland UMO-2018/29/B/NZ6/02622Wroclaw University of Science and Technology's 8211104160
6 · The paper itself

Abstract

The O'nyong-nyong virus (ONNV) is a member of the Alphavirus genus isolated for the first time in 1959 in Gulu (Uganda). The main symptoms of O'nyong-nyong fever are nonspecific and flu like; a proper diagnosis at the early stage is challenging. Until today, the first ONNV epidemic in 1959-1962 remains one of the largest arbovirus outbreaks ever recorded (over 2 million cases). No specific therapy is available thus far. Capsid protease (CP) is a chymotrypsin-like serine protease that catalyzes the autoproteolytic maturation of the structural polyprotein and undergoes self-inactivation upon the release of the mature capsid (C) protein. Despite the discovery of this virus more than 60 years ago, many aspects of CP remain understudied, including substrate specificity. Herein, the structures of the first phosphonic-type inhibitors and activity-based probes specific to the ONNV CP are presented.

Indexed as

AlphavirusAntiviral AgentsCapsid ProteinsPhosphorous AcidsProtease InhibitorsHumansMolecular StructureStructure-Activity RelationshipAntiviral AgentsCapsid ProteinsPhosphorous AcidsProtease Inhibitorsactivity‐based probesantiviral agentscapsid proteaseinhibitorsO'nyong‐nyong virus

Identifiers

PMID40192485
PMCPMC12174745

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.