ArticleAngewandte Chemie (International ed. in English)2025
A Photoactivatable Plasma Membrane Probe Based on a Self-Triggered Photooxidation Cascade for Live Cell Super-Resolution Microscopy.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Valence- and Phase-Engineered VP/WOx Heterojunction Microneedles for Photoresponsive Therapy of Infected Wounds.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- pH-modulating binary hydrogen-bonded organic frameworks accelerate diabetic wound healing.Journal of nanobiotechnology · 2026Article
- From Spark to Flame: ROS- and Light-Cascade Activatable NIR-II AIE Probe for Precise Tumor Imaging and Self-Amplifying Phototherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Photoactivatable Plasma Membrane Probe Based on a Self-Triggered Photooxidation Cascade for Live Cell Super-Resolution Microscopy.Angewandte Chemie (International ed. in English) · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Super-resolution imaging based on the localization of single emitters requires a spatio-temporal control of the ON and OFF states. To this end, photoactivatable fluorophores are adapted as they can be turned on upon light irradiation. Here, we present a concept called self-triggered photooxidation cascade (STPC) based on the photooxidation of a plasma membrane-targeted leuco-rhodamine (LRhod-PM), a non-fluorescent reduced form of a rhodamine probe. Upon visible light irradiation the small number of oxidized rhodamines, Rhod-PM, acts as a photosensitizer to generate singlet oxygen capable of oxidizing the OFF state LRhod-PM thereby switching it to its ON state. We showed that this phenomenon is kinetically favored by a high local concentration and propagates quickly when the probe is embedded in membrane bilayers. In addition, we showed that the close proximity of the dyes favors the photobleaching. At the single-molecule level, the concomitant activation/bleaching phenomena allow reaching a single-molecule blinking regime enabling single-molecule localization microscopy for super-resolution of live cellular membranes and their thin processes including filopodia and tuneling nanotubes.
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