Evidence map›Paper›PMID 40192100›Full record

ArticleAmerican journal of epidemiology2026

Associations of metal mixtures in early pregnancy with lung function and asthma in mid-childhood in Project Viva.

Ruwan Thilakaratne, Pi-I D Lin, Sheryl L Rifas-Shiman, Robert O Wright, Patrick T Bradshaw, John R Balmes, Diane R Gold, Alan Hubbard, Emily Oken, Andres Cardenas

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In one paragraph

Article in American journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruwan ThilakaratneDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA, United States.ORCID 0000-0002-6077-701X
Pi-I D LinDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, United States.
Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, United States.
Robert O WrightDepartment of Environmental Medicine and Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York City, NY, United States.
Patrick T BradshawDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA, United States.ORCID 0000-0001-7761-3129
John R BalmesDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, United States.
Diane R GoldDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Alan HubbardDivision of Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA, United States.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, United States.ORCID 0000-0003-2513-3339
Andres CardenasDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, United States.

Funding

PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERSR01ES031259 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CARDENAS, ANDRES · 2020 to 2024
$1.9M
NIEHS NIH HHS R01 ES031259United States National Institutes of Health F31ES034639United States National Institutes of Health P30-ES000002United States National Institutes of Health R01ES031259United States National Institutes of Health R01HD034568United States National Institutes of Health R24ES030894United States National Institutes of Health UH3OD023286
6 · The paper itself

Abstract

Whether fetal lung development may be vulnerable to gestational exposure to metals is unknown. We analyzed mother-child pairs in Project Viva, a prospective prebirth cohort in eastern Massachusetts, USA. Concentrations of 11 essential and nonessential metals were measured in maternal first-trimester erythrocytes (~10 weeks). Measures of lung function were obtained by spirometry, and asthma status by recall, at the mid-childhood visit (~8 years). We fit both Bayesian hierarchical models with weakly informative priors and conventional multivariable linear and logistic regressions (MLRs) to estimate associations of the metals with lung function and asthma. The analytic sample included 804 mother-child pairs (76.0% non-Hispanic White; 16.7% of children had current asthma). Each standard deviation increase in magnesium was associated with higher forced vital capacity (mean difference: 26 mL, 95% credible interval (CrI); 5, 47), higher forced expiratory volume in 1 second (FEV1) (25 mL, 95% CrI: 6, 44), and lower odds of current asthma (odds ratio: 0.88, 95% CrI: 0.71, 1.1). BHMs provided more modest and precise estimates than MLRs. Our results suggest early pregnancy intake of magnesium may enhance fetal lung development and may confer a modest reduction in the risk of asthma.

Indexed as

AsthmaLungMaternal ExposureMetalsPrenatal Exposure Delayed EffectsAdultBayes TheoremChildFemaleForced Expiratory VolumeHumansLogistic ModelsMagnesiumMaleMassachusettsPregnancyMagnesiumMetalschildren’s healthenvironmental mixtureslung functionmetalspediatric asthma

Identifiers

PMID40192100
PMCPMC13017411

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.