Evidence map›Paper›PMID 40192049›Full record

ReviewCurrent topics in medicinal chemistry2026

Advances in Cervical Cancer Diagnostics Based on Immunosensors: Innovative Approaches and Tumor Biomarkers.

Anna Paula de Oliveira Souza, Lucas Alves de Lima, Paula Angelica Burgos Ferreira, Rosa Fireman Dutra

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current topics in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anna Paula de Oliveira SouzaDepartment of Biomedical Engineering, Federal University of Pernambuco, Recife, Brazil.
Lucas Alves de LimaDepartment of Biomedical Engineering, Federal University of Pernambuco, Recife, Brazil.
Paula Angelica Burgos FerreiraDepartment of Biomedical Engineering, Federal University of Pernambuco, Recife, Brazil.
Rosa Fireman DutraDepartment of Biomedical Engineering, Federal University of Pernambuco, Recife, Brazil.ORCID 0000-0001-8314-4218

Funding

National Council for Scientific and Technological Development (CNPq), Brazil 440815/2022-3
6 · The paper itself

Abstract

Immunosensors are promising analytical tools for screening and diagnosis of cervical cancer (CC) due to being practical, rapid and economical as compared with conventional methods. Choosing a sensible and specific tumor marker (TM) serving as target which is immobilized on sensor surface is a crucial step for a CC immunosensor. In addition, the transducer design involving optical, piezoelectric or electrochemical converting of antigen-antibody interaction in the analytical signals could be projected to achieve a maximal sensitivity, guarantying accuracy in the detection of CC. This review aims to describes mostly important TMs and transducers used for development of immunosensors for CC. An overview of experimental articles published in the last decade designed to detect TM associated with CC, using optical, electrochemical and piezoelectric transductions mode are discussed. Although serological TM, such as SCCa, CEA and CA125 are still predominantly used, new biomarkers including the P16, MCM5 and PP1γ2 have been considered specific and reliable for CC diagnostic. Recently, new strategies such as multiplex assays and samples obtained directly from tumor tissue, as well self-sampling, have been proposed to overcome several limitations. Optical and electrochemical are the most popular transducers, and nanoparticles as electrochemical probes and sandwich assays have been the strategies for increasing the limit of detection and sensitivity of immunosensors for CC diagnostic.

Indexed as

Biomarkers, TumorBiosensing TechniquesUterine Cervical NeoplasmsElectrochemical TechniquesFemaleHumansImmunoassayBiomarkers, Tumorcell cycle marker.Cervical cancerimmunosensorpoint-of-care teststumor biomarker

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.