Evidence map›Paper›PMID 40192048›Full record

ArticleCurrent topics in medicinal chemistry2026

Laccaic Acid A: A Natural Anthraquinone with Potent Anticancer Activity against MDA-MB-231 Cells.

Pankaj Dagur, Suddhasattya Dey, Rajdeep Dey, Hardik Bhatt, Manik Ghosh

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Current topics in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Pankaj DagurDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra Ranchi, Jharkhand, India.
Suddhasattya DeyDepartment of Pharmaceutical Chemistry, IQ City Institute of Pharmaceutical Sciences, Durgapur, India.ORCID 0000-0002-9209-4133
Rajdeep DeyDepartment of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, 382 481 Gujarat, India.
Hardik BhattDepartment of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, 382 481 Gujarat, India.
Manik GhoshDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra Ranchi, Jharkhand, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThis study aims to isolate and evaluate the anticancer potential of laccaic acids from lac dye by utilizing polarity-based fractionation and high-performance liquid chromatography (HPLC).

methodsIn this study, polarity-based fractionation of lac dye was performed to isolate its constituents. A novel HPLC method was developed for the chromatographic separation of lac dye components, utilizing gradient elution with two solvents: 0.1% (v/v) formic acid in LCMS-grade water (A) and 90:10 acetonitrile HPLC-grade (B) at a flow rate of 0.4 mL/min. This method facilitated the isolation of four key constituents: laccaic acid D, laccaic acid B, laccaic acid C, and laccaic acid A. RESULTS AND DISCUSSION: The purity of these compounds was confirmed via LCMS methods. The anticancer activity of the isolated constituents was evaluated against the MDA-MB-231 cell line using the MTT assay. Notably, laccaic acid A demonstrated significant anticancer activity with an IC

conclusionThe results were promising, indicating that laccaic acids could offer a multifaceted approach to cancer treatment. This study highlights the potential of laccaic acids as valuable candidates for anticancer therapy and warrants further investigation into their mechanisms of action and therapeutic efficacy.

Indexed as

AnthraquinonesAntineoplastic AgentsBiological ProductsAnthracenesApoptosisAzo CompoundsCell ProliferationChromatography, High Pressure LiquidDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMDA-MB-231 CellsMolecular StructureStructure-Activity RelationshipAnthracenesAnthraquinonesAntineoplastic AgentsAzo CompoundsBiological Productslaccaic acid ACam assayCell apoptosis assayDPPH assayLaccaic acidsMTT assayTherapeutic efficacy.

Identifiers

PMID40192048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.