Evidence map›Paper›PMID 40192047›Full record

ArticleCurrent topics in medicinal chemistry2025

Synthesis of New Axially Coumarin Disubstituted Silicon(IV) Phthalocyanines, Investigation of their DNA-Binding Properties and Inhibitory Activities on Ache and Buche.

Ahmet Gunes, Furkan Meletli, Ozkan Danıs, Mehmet Salih Agırtas, Bahattin Yalcın

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Article in Current topics in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ahmet GunesMarmara University, Department of Chemistry, 34722, Kadikoy, Istanbul, Türkiye.ORCID 0000-0003-0966-4025
Furkan MeletliMarmara University, Department of Chemistry, 34722, Kadikoy, Istanbul, Türkiye.ORCID 0000-0002-9126-0486
Ozkan DanısMarmara University, Department of Chemistry, 34722, Kadikoy, Istanbul, Türkiye.ORCID 0000-0003-1781-0520
Mehmet Salih AgırtasVan Yuzuncu Yil University, Department of Chemistry, Van, Türkiye.ORCID 0000-0003-1296-2066
Bahattin YalcınMarmara University, Department of Chemistry, 34722, Kadikoy, Istanbul, Türkiye.ORCID 0000-0003-4448-1101

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn this study, we report on the synthesis and characterization of new silicon (IV) phthalocyanine compounds (SiPcs) axially substituted with coumarin-linked derivatives, designed for potential application in photodynamic therapy (PDT) due to their photophysical properties.

methodsCharacterization was carried out using FT-IR, UV-Vis, MALDI-TOF-MS, and

resultsThe compounds showed promising inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC

conclusionThe combined singlet oxygen generation, DNA binding, and enzyme inhibition data underscore the potential of these SiPc-coumarin derivatives as multifunctional agents for PDT and neuroprotective applications such as Alzheimer's disease (AD).

Indexed as

AcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsCoumarinsDNAIndolesAnimalsCattleDose-Response Relationship, DrugIsoindolesMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAcetylcholinesteraseButyrylcholinesterasecalf thymus DNACholinesterase InhibitorscoumarinCoumarinsDNAIndolesIsoindolesphthalocyanineAChEBuChEcoumarinDNA-bindingSilicon(IV) phthalocyaninessinglet oxygen.

Identifiers

PMID40192047

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.