Evidence map›Paper›PMID 40192042›Full record

ReviewCurrent pharmaceutical biotechnology2026

Dendrimers-based Hydrogels and Nanogels for Drug Delivery.

Deblina D Bhowmik, Juhi S Gupta, Pallavi A Kamandar, Amol D Gholap, Satish Rojekar, Navnath T Hatvate

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pharmaceutical biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Functional Self-Immolative Hydrogels with Dendritic Cross-Linkers for Controlled Drug Delivery.Chemistry of materials : a publication of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Deblina D BhowmikDepartment of Pharmaceutical Technology, Institute of Chemical Technology, Mumbai, Marathwada Campus, Jalna, 431203, India.
Juhi S GuptaDepartment of Pharmaceutical Technology, Institute of Chemical Technology, Mumbai, Marathwada Campus, Jalna, 431203, India.
Pallavi A KamandarDepartment of Pharmaceutical Technology, Institute of Chemical Technology, Mumbai, Marathwada Campus, Jalna, 431203, India.
Amol D GholapDepartment of Pharmaceutics, St. John Institute of Pharmacy and Research, Palghar, 401404, Maharashtra, India.
Satish RojekarDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-3301-5941
Navnath T HatvateDepartment of Pharmaceutical Technology, Institute of Chemical Technology, Mumbai, Marathwada Campus, Jalna, 431203, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current developments in nanotechnology provide an alternative therapy for various diseases by utilizing customized medicine. Among some of the nanoscale superstructures made of the hydrophilic or amphiphilic polymeric matrix are nanogels. At the same time, hydrogels are the first biomaterials created for insertion into the human body and have several biological uses. Owing to the advantages of nanogels and hydrogel, including biocompatibility, hydrophilicity, controlled drug release, and intelligent drug delivery, another macromolecule called dendrimer is incorporated into the nanogel and hydrogel for synergistic effects. In this review, we focus on the applications of dendrimer-based hydrogels and nanogels as carriers for targeted delivery of drugs. We also present the synthetic processes, different characterization methods, and challenges in incorporating the dendrimer and the drug during the preparation of nanogel and hydrogel. In recent years, the most widely used dendrimers for hydrogel formation have been reported to be poly(amidoamine) (PAMAM), phosphorous, peptide, and polyester dendrimers. Dendrimer-based hydrogel and nanogels show various applications in the treatment of a wide range of diseases, such as glaucoma, cancer, and microbial diseases. The self-cleaving mechanism of dendrimer hydrogels (DH) leads to enhanced and sustained delivery of the drugs in the treatment of cancer. Recent studies show the use of doxorubicinconjugated nanogel-based PAMAM dendrimer as a capable nanocarrier for the delivery of drugs in the treatment of cancer.

Indexed as

DendrimersDrug Delivery SystemsHydrogelsNanogelsAnimalsDrug CarriersHumansDendrimersDrug CarriersHydrogelsNanogelscombinational therapyDendrimerdrug deliverygene deliveryhydrogelimage-guided drug deliveryPTT

Identifiers

PMID40192042

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.