Evidence map›Paper›PMID 40191932›Full record

ArticleTransfusion2025

Estimating the prevalence of preoperative iron deficiency and its impact on red blood cell transfusion in adolescents undergoing scoliosis surgery: A pilot study.

Annie Qiu, Daysha Fliginger, Yona Feit, Fthimnir Hassan, Lawrence G Lenke, Guohua Li, Eldad A Hod, Lisa Eisler

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In one paragraph

Article in Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07217873 (IntraVenous Iron in Kids With Iron Deficiency and Scoliosis), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07217873 phase2 / phase3recruitingnot on this map

IntraVenous Iron in Kids With Iron Deficiency and Scoliosis

TypeinterventionalSponsorColumbia UniversityRan2025 to 2027Enrolled120ConditionsScoliosis Correction, Iron Deficiency, Transfusion Blood, Surgery ComplicationsArmsFerric carboxymaltose IV, Normal Saline (Placebo)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Annie QiuDepartment of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Daysha FligingerDepartment of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Yona FeitDepartment of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Fthimnir HassanDepartment of Orthopedic Surgery, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Lawrence G LenkeDepartment of Orthopedic Surgery, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Guohua LiDepartment of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Eldad A HodDepartment of Orthopedic Surgery, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.ORCID https://orcid.org/0000-0002-2367-9509
Lisa EislerDepartment of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.ORCID https://orcid.org/0000-0001-9726-2354

Funding

Efficacy of Preoperative Oral Iron Supplementation in Adolescents Undergoing Scoliosis SurgeryK23GM152933 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Lisa Danielle Eisler · 2023 to 2026
$771k
National Institute of General Medical Sciences, National Institutes of Health K23GM152933NIGMS NIH HHS K23 GM152933Society for the Advancement of Patient Blood Management
6 · The paper itself

Abstract

backgroundIron deficiency (ID) is the leading cause of anemia, contributes to reduced physical and cognitive performance, and increases the likelihood of red blood cell (RBC) transfusion in surgical patients. Adolescents undergoing scoliosis surgery are not routinely screened for ID, though they are at heightened risk of anemia and other adverse effects. STUDY DESIGN AND

methodPatients aged 11-18 years undergoing scoliosis surgery from September 2021 through August 2023 at our institution were approached for participation in a pilot study examining iron and hematologic parameters from the preoperative period through surgical recovery and their association with RBC transfusion.

resultsClinical and laboratory data were obtained from a convenience sample of 46 adolescents (33 females, 13 males), of whom 17.4% (8/46) were anemic and 33.3% (14/42) were iron deficient. ID was more common in female patients (p = .017). RBC transfusions were given in 10.9% (5/46) of patients, more often in those with ID than without (28.6% vs. 3.6%, respectively, p = .018). At a clinic visit several weeks after surgery, 50% (12/24) of patients tested were anemic, while 74% (17/23) had low iron stores.

conclusionsFindings from this pilot study suggest that ID is present in over 30% of adolescents undergoing scoliosis surgery and is associated with a greater likelihood of receiving an RBC transfusion, while most patients had low iron stores during surgical recovery. Larger studies are needed to confirm the extent to which preoperative ID impacts the likelihood of RBC transfusion and to evaluate the benefit of iron supplementation.

Indexed as

Anemia, Iron-DeficiencyErythrocyte TransfusionIron DeficienciesScoliosisAdolescentChildFemaleHumansMalePilot ProjectsPreoperative PeriodPrevalenceiron deficiencyscoliosistransfusion

Identifiers

PMID40191932
PMCPMC12088881

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.