Evidence map›Paper›PMID 40191897›Full record

ReviewJournal of neurochemistry2025

α2δ-1-Linked NMDA and AMPA Receptors in Neuropathic Pain and Gabapentinoid Action.

Yuying Huang, Shao-Rui Chen, Hui-Lin Pan

Abstract readReview
In one paragraph

Review in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. HIV-1 gp120 Induces Nociceptive Hypersensitivity via α2δ-1-Bound NMDA Receptors at Primary Afferent→Excitatory Neuron Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuying HuangDepartment of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Shao-Rui ChenDepartment of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Hui-Lin PanDepartment of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-8444-3770

Funding

Molecular Determinants of Synaptic Plasticity in Chronic PainR01NS101880 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Shao-Rui Chen, Hui-Lin Pan · 2017 to 2026
$4.1M
Signaling Mechanisms of Opioid-Induced Hyperalgesia and ToleranceR01DA041711 · NIDA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Shao-Rui Chen, Hui-Lin Pan · 2017 to 2026
$3.8M
Neural Mechanisms of Calcineurin Inhibitor-Induced HypertensionR01HL154512 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PAN, HUI-LIN · 2020 to 2023
$2.3M
Mechanisms of Epigenetic Plasticity in Neuropathic PainR01NS132398 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Shao-Rui Chen, Hui-Lin Pan · 2023 to 2026
$1.8M
Neuronal Plasticity and Signaling in Neuropathic PainR01NS073935 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PAN, HUI-LIN · 2011 to 2015
$1.8M
Mechanisms of Neuronal Plasticity in Neuropathic PainR01GM120844 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PAN, HUI-LIN · 2016 to 2019
$1.6M
NHLBI NIH HHS R01 HL154512NIDA NIH HHS R01 DA041711NIGMS NIH HHS R01 GM120844NINDS NIH HHS R01 NS073935NINDS NIH HHS R01 NS101880NINDS NIH HHS R01 NS132398
6 · The paper itself

Abstract

Chronic neuropathic pain is a debilitating condition that presents a significant therapeutic challenge. Unlike nociceptive pain, neuropathic pain is predominantly driven by glutamate NMDA receptors (NMDARs) and/or Ca

Indexed as

AnalgesicsCalcium ChannelsGabapentinNeuralgiaReceptors, AMPAReceptors, N-Methyl-D-AspartateAnimalsHumansAnalgesicsCACNA2D1 protein, humanCalcium ChannelsGabapentinReceptors, AMPAReceptors, N-Methyl-D-Aspartatedorsal root gangliongabapentinoidionotropic glutamate receptorprimary sensory neuronsynaptic plasticityvoltage‐gated calcium channel

Identifiers

PMID40191897
PMCPMC11995887

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.