Evidence map›Paper›PMID 40191796›Full record

ArticleFrontiers in nutrition2025

Chloride channel-3 regulates sodium-iodide symporter expression and localization in the thyroids of mice on a high-iodide diet.

Meisheng Yu, Zhiqin Deng, Ke Wang, Xiangzhong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Meisheng YuDepartment of Hematology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhiqin DengHand and Foot Surgery Department, The First Hospital Affiliated to Shenzhen University, Shenzhen, China.
Ke WangDepartment of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Xi'an Medical University, Xi'an, China.
Xiangzhong ZhangDepartment of Hematology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Certain chloride channels and H Methods: The expression and localization of ClC-3 in wild-type (WT), ClC-3 overexpression (OE) and ClC-3 knockout (KO) were detected by Western blotting (WB), immunohistochemistry and immunofluorescence, respectively. The Results: ClC-3 expressions in thyrocytes were primarily localized to the basolateral and lateral membranes, in both ClC-3 OE and WT mice groups under normal I Discussion: These findings suggest that ClC-3 may regulate NIS function via ROS signaling under excessive iodide conditions.

Indexed as

basolateral and lateral membraneschloride channel 3iodide conditionsiodide excessreactive oxygen speciessodium-iodide symporterthyroid gland

Identifiers

PMID40191796
PMCPMC11968397

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.