Evidence map›Paper›PMID 40191697›Full record

ArticleDrug target insights

Nidhi Thakkar, Gemini Gajera, Dilip Mehta, Sujit Nair, Vijay Kothari

Abstract read
In one paragraph

Article in Drug target insights. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. bioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Review
  4. Drug target insights
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nidhi ThakkarInstitute of Science, Nirma University, Ahmedabad - India.ORCID https://orcid.org/0009-0005-6781-4441
Gemini GajeraInstitute of Science, Nirma University, Ahmedabad - India.ORCID https://orcid.org/0000-0002-1604-912X
Dilip MehtaPhytoveda Pvt. Ltd., Mumbai - India.ORCID https://orcid.org/0000-0003-4076-1480
Sujit NairPhytoveda Pvt. Ltd., Mumbai - India.ORCID https://orcid.org/0000-0002-7322-7375
Vijay KothariInstitute of Science, Nirma University, Ahmedabad - India.ORCID https://orcid.org/0000-0003-1035-7217

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: The extract's effect on worm lifespan and fertility was observed microscopically. Worm motility was quantified through an automated worm tracker. The metabolic activity of the worms was captured using the Alamar Blue® assay. Differential gene expression in extract-treated worms was revealed through a whole transcriptome approach. Results: Extract-exposed gnotobiotic worms, in the absence of any bacterial food, registered longer lifespan, higher fertility, better motility, and metabolic activity. Whole transcriptome analysis of the extract-treated worms revealed the differential expression of the genes associated with lifespan extension, eggshell assembly and integrity, progeny formation, yolk lipoproteins, collagen synthesis, cuticle molting, etc. This extract seems to exert its beneficial effect on Conclusions: Our results validate the suitability of

Indexed as

Caenorhabditis elegansFertilityHealthspanHealthy agingLongevityNetwork analysisNutraceuticalWithania somnifera rootWorm transcriptome

Identifiers

PMID40191697
PMCPMC11969495

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.