ArticleJournal of medical signals and sensors2025
Rifampin-loaded Mesoporous Silica Nanoparticles Improved Physical and Mechanical Properties and Biological Response of Acrylic Bone Cement.
Article in Journal of medical signals and sensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Research progress of implantable materials in antibacterial treatment of bone infection.Frontiers in bioengineering and biotechnology · 2025Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acrylic bone cement, which is used to fix implants in the knee and hip, is prone to contamination with various types of infections. Adding small amounts of different antibiotics to the cement can help prevent and treat infections. Rifampin antibiotic has been added to bone cement to create an appropriate antimicrobial response in the treatment of resistant coagulase-negative staphylococci (CoNS) biofilms, but there are some challenges such as reducing mechanical properties and prolonging the setting time of the cement. Loading the antibiotic in the nanoparticle could eliminate these challenges. Methods: In this study, rifampin-loaded mesoporous silica nanoparticles (MSNs) were added to bone cement, and the polymerization components, mechanical properties, drug release, antibacterial activity, and cellular response were investigated and compared with commercial pure cement and the cement containing free rifampin. Results: Loading rifampin into MSN improved compressive strength by 57.52%. Cement containing rifampin loaded into MSN showed remarkable success in antibacterial activity. The growth inhibition zone created by it in the culture medium of Conclusion: Rifampin loading in MSN limited the reduction of cement strength. It also improved the drug release pattern and prevented antibiotic resistance.
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