Evidence map›Paper›PMID 40191662›Full record

ArticleJournal of surgical case reports2025

Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) in the non-ampullary region of the duodenum: a case report.

Kazuki Matsushita, Atsushi Urakami, Masaki Matsubara, Akihisa Akagi, Takashi Urano, Naomasa Ishida, Munenori Takaoka, Hideyo Fujiwara, Takashi Akiyama, Tomoki Yamatsuji

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kazuki MatsushitaDepartment of General Surgery, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama 700-8505, Japan.
Atsushi UrakamiDepartment of General Surgery, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama 700-8505, Japan.ORCID https://orcid.org/0009-0009-8214-9338
Masaki MatsubaraDepartment of General Surgery, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama 700-8505, Japan.
Akihisa AkagiDepartment of General Surgery, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama 700-8505, Japan.
Takashi UranoDepartment of General Surgery, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama 700-8505, Japan.
Naomasa IshidaDepartment of General Surgery, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama 700-8505, Japan.
Munenori TakaokaDepartment of General Surgery, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama 700-8505, Japan.
Hideyo FujiwaraDepartment of Pathology, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama 700-8505, Japan.
Takashi AkiyamaDepartment of Pathology, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama 700-8505, Japan.
Tomoki YamatsujiDepartment of General Surgery, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama 700-8505, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs), a very rare form of neuroendocrine neoplasm (NEN), are associated with poor prognosis. Herein, we present a rare case of duodenal MiNEN composed of neuroendocrine carcinoma (NEC) and adenocarcinoma in a non-ampullary lesion. A 70-year-old male referred to our hospital was found to have duodenal perforation with a tumor in the 2nd duodenal portion based on computed tomography. Biopsy revealed a poorly differentiated adenocarcinoma. Three weeks following emergency surgery for the perforation, pancreaticoduodenectomy of the duodenal tumor was performed. The resected specimen comprised a 45 × 35-mm protruding and circumferential tumor extracted from the 2nd portion, with no involvement of the papilla of Vater. Histopathological examination revealed coexisting poorly differentiated adenocarcinoma and NEC components. The final pathological diagnosis was MiNEN (por2 > sig + NEC). TNM: pT4b (SE), pN2, M0, pStageIIIb. The postoperative course was uneventful, developing peritoneal dissemination and multiple bone metastasis after 5 months, with death 7 months postoperatively.

Indexed as

duodenal cancerduodenal tumormixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN)neuroendocrine carcinoma (NEC)neuroendocrine neoplasms (NENs)

Identifiers

PMID40191662
PMCPMC11971567

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.