Evidence map›Paper›PMID 40191462›Full record

Articlenpj drug discovery2025

Structural and mechanistic study of a novel inhibitor analogue of

Amit K Verma, Robbert Q Kim, Dirk A Lamprecht, Clara Aguilar-Pérez, Sarah Wong, Nicolas Veziris, Alexandra Aubry, José M Bartolomé-Nebreda, Rodrigo J Carbajo, Jennefer Wetzel and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj drug discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The role of cytochrome bcNature communications · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amit K VermaDepartment of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.
Robbert Q KimDepartment of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.
Dirk A LamprechtJanssen Pharmaceutica, Global Public Health, Turnhoutseweg 30, 2340 Beerse, Belgium.
Clara Aguilar-PérezJanssen Pharmaceutica, Global Public Health, Turnhoutseweg 30, 2340 Beerse, Belgium.
Sarah WongSorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, U1135, AP-HP. Sorbonne-Université, Fédération de Bactériologie, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Paris, France.
Nicolas VezirisSorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, U1135, AP-HP. Sorbonne-Université, Fédération de Bactériologie, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Paris, France.
Alexandra AubrySorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, U1135, AP-HP. Sorbonne-Université, Fédération de Bactériologie, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Paris, France.
José M Bartolomé-NebredaGlobal Discovery Chemistry, Janssen-Cilag, S.A., a Johnson & Johnson Innovative Medicine company, c/ Jarama, 75 A, 45007 Toledo, Spain.
Rodrigo J CarbajoIn Silico Discovery, Janssen-Cilag, S.A., a Johnson & Johnson Innovative Medicine Company, c/ Jarama, 75A, 45007 Toledo, Spain.
Jennefer WetzelJanssen Pharmaceutica, Global Public Health, Turnhoutseweg 30, 2340 Beerse, Belgium.
Meindert H LamersDepartment of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-resistant tuberculosis (TB) continues to challenge treatment options, necessitating the exploration of new compounds of novel targets. The mycobacterial respiratory complex cytochrome bc

Indexed as

Drug discoveryTarget validation

Identifiers

PMID40191462
PMCPMC11964921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.