ArticleNeuroimage. Reports2025
Cholinergic neurotransmission in the anterior cingulate cortex is associated with cognitive performance in healthy older adults: Baseline characteristics of the Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) trial.
Article in Neuroimage. Reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04149457 (Improving Neurological Health in Aging Via Neuroplasticity-based Computerized Exercise), which is not on this map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Neurological Health in Aging Via Neuroplasticity-based Computerized Exercise (INHANCE)
Who cites it
5 citing papers in PubMed.
- Whole-brain cholinergic modulation following computerized cognitive training in healthy older adults: a [18F]FEOBV PET study.GeroScience · 2026Article
- Article
- Neurobiological Synergy of Plant and Animal Sources of Omega-3 and Exercise in Aging: Implications for Molecular Signaling, Memory, Spatial Learning, and Brain Function.Food science & nutrition · 2025Review
- Bringing Executive Function Testing Online: Assessment Validation Study.JMIR formative research · 2025Article
- Association of a Brief Computerized Cognitive Assessment With Cholinergic Neurotransmission: Assessment Validation Study.JMIR formative research · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Aging is associated with dysfunction in the cholinergic system, including degeneration of basal forebrain cholinergic terminals that innervate the cortex, which directly contributes to age- and disease-related cognitive decline. In this study, we used [18F]fluoroethoxybenzovesamicol ([18F]FEOBV) positron emission tomography (PET) imaging to assess the effect of age on cholinergic terminal integrity in predefined regions of interest and its relationship to cognitive performance in healthy older adults who underwent neuropsychological assessment and FEOBV PET brain imaging. Our results showed age-related reductions in FEOBV binding, particularly in the anterior cingulate cortex-the primary region of interest-as well as in the striatum, posterior cingulate cortex, and primary auditory cortex. Notably, FEOBV binding in the anterior cingulate cortex was positively correlated with cognitive performance on the NIH EXAMINER Executive Composite Score. These findings suggest that [18F] FEOBV PET imaging can be used as a reliable biomarker to assess cholinergic changes in the human brain and indicate that preserving the cholinergic integrity of the basal forebrain may help maintain cognitive function and protect against age-related cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.