Evidence map›Paper›PMID 40191366›Full record

ArticleACS omega2025

Aminoquinoline-Pyrimidine-Based Alkyl-Piperazine Tethered Hybrids: Synthesis, Antiplasmodial Activity, and Mechanistic Studies.

Srishti Rawat, Anuj Thakur, Shabana I Khan, Rohit Kholiya, Babu L Tekwani, Aparna Bahuguna, Diwan S Rawat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Srishti RawatDepartment of Chemistry, University of Delhi, Delhi 110007, India.
Anuj ThakurDepartment of Chemistry, University of Delhi, Delhi 110007, India.
Shabana I KhanNational Centre for Natural Products Research, University of Mississippi, Oxford, Mississippi 38677, United States.ORCID https://orcid.org/0000-0001-6429-7219
Rohit KholiyaDepartment of Chemistry, University of Delhi, Delhi 110007, India.
Babu L TekwaniNational Centre for Natural Products Research, University of Mississippi, Oxford, Mississippi 38677, United States.
Aparna BahugunaDepartment of Chemistry, University of Delhi, Delhi 110007, India.
Diwan S RawatDepartment of Chemistry, University of Delhi, Delhi 110007, India.ORCID https://orcid.org/0000-0002-5473-7476

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Though great progress has been made to eliminate malaria globally, effective and inexpensive strategies to design new antimalarials are still required due to the problem of drug resistance to the currently used antimalarials. Herein, in continuation of our efforts to improve the therapeutic efficacy of 4-aminoquinoline-pyrimidine (4-AQ-Py) based molecular hybrids, a series of 4-AQ-Py hybrids linked through diamine-piperazine (flexible and rigid) linkers was synthesized and assessed for

Identifiers

PMID40191366
PMCPMC11966289

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.