ArticleACS omega2025
Stability of Oxytetracycline in Different Types of Solutions and Stored at Different Temperatures.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Administration of drugs, especially antibiotics, via intravenous injections with different types of solutions is a common and widely applied treatment method in human and veterinary medicine. One of these antibiotics is oxytetracycline, which is a tetracycline. The aim of this article is to study the effect of temperature (5 °C, 40 °C) and light on the stability of oxytetracycline injections after dissolving different types of reconstitution solutions (sodium chloride 0.9%, dextrose 5%, sodium chloride 0.9% with dextrose 5%, Ringer). After 24 h, the concentration of the oxytetracycline was determined by the HPLC method. The results showed a decrease in the concentration of oxytetracycline due to the effect of high temperature (40 °C) and light in all solutions. On the other hand, the decrease in the concentration of oxytetracycline was less than on low temperature (5 °C) and light protection. The effect of the solution reconstitution solution was also evaluated where the stability of oxytetracycline was best in dextrose 5% solution, followed by sodium chloride 0.9%, Ringer's solution, and mixed (dextrose with sodium chloride 0.9%). This paper recommends reconstituting oxytetracycline with 5% dextrose and storage under refrigeration away from light to maintain a better stability of oxytetracycline.
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