Evidence map›Paper›PMID 40191331›Full record

ArticleACS omega2025

Functional Characterization of Cytochromes P450 Linked to Herbicide Detoxification and Selectivity in Winter Wheat and the Problem Competing Weed Blackgrass.

Alina Goldberg-Cavalleri, Sara Franco-Ortega, Stewart Brown, Andrew Walker, Blandine Rougemont, John Sinclair, Melissa Brazier-Hicks, Richard Dale, Nawaporn Onkokesung, Robert Edwards

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alina Goldberg-CavalleriSchool of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
Sara Franco-OrtegaSchool of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
Stewart BrownSchool of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
Andrew WalkerSchool of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
Blandine RougemontSyngenta, Jealott's Hill, Bracknell, Berkshire, Warfield RG42 6EY, U.K.
John SinclairSyngenta, Jealott's Hill, Bracknell, Berkshire, Warfield RG42 6EY, U.K.
Melissa Brazier-HicksSyngenta, Jealott's Hill, Bracknell, Berkshire, Warfield RG42 6EY, U.K.
Richard DaleSyngenta, Jealott's Hill, Bracknell, Berkshire, Warfield RG42 6EY, U.K.
Nawaporn OnkokesungSchool of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
Robert EdwardsSchool of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.ORCID https://orcid.org/0000-0003-0809-5991

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The selective chemical control of wild grasses in wheat is primarily determined by the relative rates of herbicide metabolism, with the superfamily of cytochromes P450 (CYPs) playing a major role in catalyzing phase 1 detoxification reactions. This selectivity is enhanced by herbicide safeners, which induce CYP expression in cereals, or challenged by the evolution of nontarget site resistance (NTSR) in weeds such as blackgrass. Using transcriptomics, proteomics, and functional expression in recombinant yeast, CYPs linked to safener treatment and NTSR have been characterized in wheat and blackgrass. Safener treatment resulted in the induction of 13 families of CYPs in wheat and 5 in blackgrass, with CYP71, CYP72, CYP76, and CYP81 members active toward selective herbicides in the crop. Based on their expression and functional activities, three inducible

Identifiers

PMID40191331
PMCPMC11966285

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.