ArticleACS omega2025
Discovery of a New Class of Thiazolidin-4-one-Based Inhibitors of Human Dihydroorotate Dehydrogenase: Biological Activity Evaluation, Molecular Docking, and Molecular Dynamics.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Machine learning-assisted screening of natural product database for the identification of novel chalcone-based derivative as a potent DHODH inhibitor in cancer therapy.Discover oncology · 2026Article
- Identification of novel dihydroorotate dehydrogenase (DHODH) inhibitors for cancer: computational drug repurposing strategy.BMC pharmacology & toxicology · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The continuous outbreak of various viruses reminds us to prepare broad-spectrum antiviral drugs. Human dihydroorotate dehydrogenase (hDHODH) inhibitor exhibits broad-spectrum antiviral effects. In order to explore the novel type of human dihydroorotate dehydrogenase inhibitor (hDHODHi), we have optimized, designed, and synthesized 17 compounds and conducted biological activity evaluation, molecular docking, and molecular dynamics studies. The results of biological activity evaluation showed that compounds 10 and 16 exhibited submicromolar inhibitory activity, with IC
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Registered trials
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