ArticleACS omega2025
Designing Porosity-Tailored Hydrogel Sponges with Controlled Cell Positioning Using Dispersible, Autofragmented Sacrificial Microfibers.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Hydrogel encapsulation is a rational approach that facilitates three-dimensional inoculation, arrangement, and culture of living mammalian cells for biomedical applications. However, strategies to form capillary-like conduits in hydrogels remain challenging due to low spatial resolution and difficulty in controlling the location of multiple cell types. Herein, we propose a highly unique process of constructing hydrogel sponges with tailored pore densities using finely fragmented microfibers as sacrificial porogens. A facile production process for automatically fragmented hydrogel microfibers (AF fibers) was developed through micronozzle-assisted hydrodynamic spinning and shear force application during gelation. Hydrogel sponges were prepared using photo-cross-linkable gelatin as the matrix and AF fibers dispersed in the precursor solution. We cultured liver cells in the sponges and evaluated the morphology and pore connectivity of the sponges and cellular functions. Furthermore, to create tissue models highly mimicking the cellular assembly
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Registered trials
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