ArticleJBMR plus2025
Bone mineral density and cardiovascular diseases: a two-sample Mendelian randomization study.
Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association between bone health and cardiovascular events in a population-based cohort.Archives of osteoporosis · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The link between BMD and cardiovascular disease (CVD) remains a topic of extensive debate in observational studies, with inconsistent reports regarding the causality of this relationship. This study implements robust methodologies to evaluate the causal relationship between BMD and various CVDs. Two sample Mendelian randomization (MR) method was used to estimate the relationship between genetically predicted BMD and seven key CVDs: atrial fibrillation and flutter, angina, ischemic heart disease, heart failure, hypertension, myocardial infarction, and non-ischemic cardiomyopathy. Data were obtained from independent publicly available genome-wide association studies (GWAS) for BMD and CVDs, using two separate datasets for the cardiovascular outcomes: the UK Biobank cohort (primary analysis) and the FinnGen cohort (validation analysis). The MR Pleiotropy RESidual Sum and Outlier test assessed the heterogeneity and pleiotropy of selected instrumental variables (IVs). We applied the inverse variance weighted model (IVW), weighted median, weighted mode method, and MR-Egger regression model to estimate causal effects. MR results indicate no relationship between BMD and atrial fibrillation and flutter (IVW, beta-estimate: 0.011, SE: 0.03,
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Registered trials
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