Evidence map›Paper›PMID 40191057›Full record

ArticleJournal of contemporary brachytherapy2025

Skin marker for MR-only surface high-dose-rate brachytherapy.

Evangelia Kaza, Phillip M Devlin, Desmond O'Farrell, Ivan Buzurovic

Abstract read
In one paragraph

Article in Journal of contemporary brachytherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Evangelia KazaBrigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Phillip M DevlinBrigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Desmond O'FarrellBrigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Ivan BuzurovicBrigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Recent advances in surface high-dose-rate (HDR) brachytherapy imaging indicate that flap applicators, human skin, and fibromatosis can be visualized using MRI. Complete MR-only surface brachytherapy workflows would require skin marker identification to define clinical target edges. However, CT markers are not detected on MR images, and common MR markers are unsuitable for continuous surface target tracing. In this paper, we proposed an alternative skin marker that was evaluated for MRI and CT detectability and contourability using a brachytherapy treatment planning system (TPS). Material and methods: Commercially obtained silicone rubber tubes of 2 or 3 mm diameter were taped on the hand of an anthropomorphic phantom, a healthy volunteer, and three palmar fascial fibromatosis patients. Subjects were imaged with an optimized 3D pointwise encoding time reduction with radial acquisition (PETRA) sequence, and a volumetric interpolated breath-hold examination (VIBE) sequence with Dixon reconstruction. Additionally, patients underwent standard CT imaging. Obtained images were reviewed for tube conspicuity, and tubes were tracked on axial views using Oncentra Brachy TPS. Independent tube and muscle reference contours were drawn in MIM for quantitative analysis, considering the three orthogonal imaging planes. Results and Conclusions: Silicone rubber tubes were detected with positive signal on PETRA, VIBE, and CT images. Among the MR series, Dixon VIBE fat-only showed the highest contrast against muscle tissue and the best separation from human skin, followed by DIXON opposed-phase. 3 mm diameter tubes were tracked better by TPS than 2 mm diameter ones. Considering MR images in the three orthogonal planes in MIM was more helpful for localizing the entire tube than using axial images only in TPS. All obtained contour shapes generally agreed with the known tube positions. Overall, solid silicone rubber tubes of 3 mm diameter represent a suitable skin marker alternative to CT markers for MR-only surface HDR brachytherapy.

Indexed as

MRIskin HDR brachytherapysurface markers

Identifiers

PMID40191057
PMCPMC11966218

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.