Evidence map›Paper›PMID 40191056›Full record

ArticleJournal of contemporary brachytherapy2025

Efficacy of medial needles in mitigating dose deficits from sub-optimally inserted tandems in cervical interstitial brachytherapy.

Maryam Ejaz, Sameed Hussain, Abdus Samad Syed, Muhammad Sohaib Nadeem, Muhammad Shehwar Khan

Abstract read
In one paragraph

Article in Journal of contemporary brachytherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maryam EjazDepartment of Radiation Oncology, Combined Military Hospital Lahore, Pakistan.
Sameed HussainDepartment of Radiation Oncology, Combined Military Hospital Lahore, Pakistan.
Abdus Samad SyedDepartment of Radiation Oncology, Combined Military Hospital Lahore, Pakistan.
Muhammad Sohaib NadeemDepartment of Radiation Oncology, Combined Military Hospital Lahore, Pakistan.
Muhammad Shehwar KhanDepartment of Radiation Oncology, Combined Military Hospital Lahore, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: In cervical interstitial brachytherapy, sub-optimal tandem insertion can lead to inadequate dose coverage of clinical target volume (CTV). This study aimed to evaluate the effectiveness of medial interstitial needles in optimizing dose to CTV, while minimizing toxicity to organs at risk (OARs), such as bladder, rectum, and sigmoid colon. Material and methods: The study included 25 brachytherapy plans in seven subjects with locally advanced cervical cancer, who had sub-optimal tandem insertions during cervical interstitial brachytherapy, for which 1 or more medial needle was inserted Results: Compared with plans without medial needles (x̄ = 5.22 ±1.60 Gy, median = 5.68 Gy), the plans with medial needles activated (x̄ = 6.59 ±1.55 Gy, median = 7.08 Gy) achieved 26.2% and 24.6% improvement ( Conclusions: In patients with sub-optimal tandem insertion, the placement of medial needles can compensate dose deficit, while keeping OARs doses within acceptable constraints. Further studies among larger cohorts are warranted to optimize treatment protocol.

Indexed as

brachytherapycervical cancerdose optimizationinterstitial needlessub-optimal tandem insertionUtrecht applicator

Identifiers

PMID40191056
PMCPMC11966221

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.