ArticleImaging neuroscience (Cambridge, Mass.)2025
Velocity-selective arterial spin labelling bolus duration measurements: Implications for consensus recommendations.
Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI.Experimental physiology · 2025Review
- MULti-TImepoint VElocity-selective Reconciled with Spatially-sElective (MULTIVERSE) ASL: Improving robustness to both shortened and prolonged arterial transit time.Magnetic resonance in medicine · 2025Article
- Evaluating cerebrovascular reactivity measured by velocity selective inversion arterial spin labeling with different post-labeling delays: The effect of fast flow.Magnetic resonance in medicine · 2024Article
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Authors and funding
8 authors.
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Abstract
Velocity-selective arterial spin labelling (VSASL) MRI is insensitive to prolonged arterial transit time. This is an advantage over other arterial spin labelling schemes, where long arterial transit times can lead to bias. Therefore, VSASL can be used with greater confidence to study perfusion in the presence of long arterial transit times, such as in the ageing brain, in vascular pathologies, and cancer, or where arterial transit time changes, such as during measurement of cerebrovascular reactivity (CVR). However, when calculating perfusion (cerebral blood flow, CBF, in the brain) from VSASL signal, it is assumed that a vascular crushing module, defining the duration of the bolus, is applied before the arrival of the trailing edge. The early arrival of the trailing edge of the labelled bolus of blood will cause an underestimation of perfusion. Here we measure bolus duration in adult, healthy human brains, both at rest and during elevated CBF during CO
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