ArticleInterface focus2025
Exercise modulates brain pulsatility: insights from q-aMRI and MRI-based flow methods.
Article in Interface focus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Orchestrating brain fluid dynamics: circadian regulation of CSF, glymphatic exchange, and waste clearance.Frontiers in cell and developmental biology · 2026Review
- A mechanistic approach for intracranial pressure (ICP) level estimation.Scientific reports · 2025Article
- Relationship between impaired cerebral lymphatic function and iron deposition, blood flow in VaD: a clinical MRI study.Frontiers in neuroscience · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates intracranial dynamics following the Monro-Kellie doctrine, depicting how brain pulsatility, cerebrospinal fluid (CSF) flow and cerebral blood flow (CBF) interact under resting and exercise conditions. Using quantitative amplified magnetic resonance imaging (q-aMRI) alongside traditional MRI flow metrics, we measured and analysed blood flow, CSF dynamics and brain displacement in a cohort of healthy adults both at rest and during low-intensity handgrip exercise. Exercise was found to reduce pulsatility in CBF while increasing CSF flow and eliminating CSF regurgitation, highlighting a shift towards more sustained forward flow patterns (from cranial to spinal compartments). Displacement analysis using q-aMRI revealed a consistent trend of reduced whole brain motion during exercise, though as the sample of data that met quality control was low (
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Registered trials
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