Evidence map›Paper›PMID 40191016›Full record

ArticleResearch in autism spectrum disorders2023

Are There Sex Differences in Interactive Associations of Environmental Exposure to Lead (Pb), Mercury (Hg), and Manganese (Mn) with GST Genes (

Hiba T Zwiya, Maureen Samms-Vaughan, Jan Bressler, MinJae Lee, Courtney Byrd-Williams, Manouchehr Hessabi, Megan L Grove, Sydonnie Shakespeare-Pellington, Katherine A Loveland, Mohammad H Rahbar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research in autism spectrum disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hiba T ZwiyaDepartment of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Maureen Samms-VaughanDepartment of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston, Kingston 7, Jamaica.
Jan BresslerDepartment of Epidemiology, Human Genetics, and Environmental Sciences, and Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
MinJae LeePeter O'Donnell Jr. School of Public Health, and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Courtney Byrd-WilliamsDepartment of Health Promotion and Behavioral Sciences, and Michael & Susan Dell Center for Healthy Living, School of Public Health Regional Campus at Austin, The University of Texas Health Science Center at Houston, Austin, Texas 78701, USA.
Manouchehr HessabiBiostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Megan L GroveDepartment of Epidemiology, Human Genetics, and Environmental Sciences, and Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Sydonnie Shakespeare-PellingtonDepartment of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston, Jamaica.
Katherine A LovelandLouis A. Faillace, MD Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Mohammad H RahbarDepartment of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, and Division of Clinical and Translational Sciences, Department of Internal Medicine, McGovern Medical School, and Biostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.

Funding

Convalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3M
U OF TEXAS HLTH SCI CTR HOUSTON CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCESUL1RR024148 · NCRR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2006 to 2010
$27.9M
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
Epidemiological Research on Autism in Jamaica - Phase IIR01ES022165 · NIEHS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI RAHBAR, MOHAMMAD HOSSEIN · 2013 to 2018
$2.8M
Epidemiological Research on Autism in JamaicaR21HD057808 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI RAHBAR, MOHAMMAD HOSSEIN · 2009 to 2010
$278k
NCATS NIH HHS UL1 TR000371NCATS NIH HHS UL1 TR003167NCRR NIH HHS UL1 RR024148NICHD NIH HHS R21 HD057808NIEHS NIH HHS R01 ES022165
6 · The paper itself

Abstract

Background: Male preponderance is well-established in children with autism spectrum disorder (ASD). Glutathione S-transferase (GST) genes play a crucial role in suppressing oxidative stress triggered by environmental stressors. Objective: To determine whether the association between metals and ASD differs by sex and by GST genes. Methods: Using data from 344 pairs of sex-and age-matched cases and controls, we assessed the association of each metal with ASD or ASD severity, by applying conditional logistic regression (CLR) or general linear models (GLM). Sex was assessed as an effect modifier in separate GST genetic models. Results: For Pb exposure, using a recessive model for the Conclusion: The association of Pb and Hg with ASD significantly differed by sex under the

Indexed as

Autism Spectrum Disorder (ASD)Glutathione S-transferase (GST) genesHeavy metals (Lead, Mercury, Manganese)InteractionSex Differences

Identifiers

PMID40191016
PMCPMC11970619

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.