ArticleCureus2025
Vitamin D Deficiency and Its Impact on Prediction and Treatment of Postoperative Hypocalcemia in a Cohort of Patients Undergoing Total Thyroidectomy.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPostoperative hypocalcemia is a common complication following total thyroidectomy, leading to extended hospital stays, decreased patient quality of life, and increased healthcare costs. Recent research has explored the role of preoperative vitamin D deficiency in exacerbating this risk due to its impact on calcium homeostasis.
methodsA prospective study was conducted at a tertiary care hospital in Southern India from March 2023 to May 2024. Patients undergoing total thyroidectomy were categorized into three groups based on their preoperative vitamin D status: Group A (Vitamin D sufficient), Group B (Vitamin D deficient with preoperative supplementation), and Group C (Vitamin D deficient without supplementation). Serum calcium levels were monitored preoperatively and postoperatively to assess for hypocalcemia.
resultsA total of 84 patients were included: Group A (n=38), Group B (n=23), and Group C (n=23). Preoperative vitamin D levels were significantly lower in Groups B and C compared to Group A. The incidence of postoperative hypocalcemia was highest in Group C (n=23; 56.5%), followed by Group A (n=38; 42.1%) and Group B (n=23; 34.8%), although differences were not statistically significant (p=0.315). However, clinical hypocalcemia was significantly higher in Group C (n=23; 56.5%) compared to Group A (n=38; 23.7%) and Group B (n=23; 21.7%) (p=0.013).
conclusionPreoperative vitamin D deficiency is associated with an increased risk of postoperative hypocalcemia following total thyroidectomy. Preoperative supplementation in vitamin D-deficient patients may mitigate this risk, suggesting a potential benefit in routine assessment and correction of vitamin D status before surgery to optimize patient outcomes.
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