ReviewCureus2025
Spectrum of Neurological Complications in Sjögren's Syndrome: A Comprehensive Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pulmonary amyloidosis, gastric MALT lymphoma, and multiple sclerosis in a patient with Sjögren's disease: a case report and review of the literature.Rheumatology international · 2026Pooled it
- Beyond Dryness: Mapping the Psychological and Cognitive Burden in Sjögren's Disease-A Narrative Review.Journal of clinical medicine · 2026Review
- Neuroimmunological overlap syndromes in optic neuritis, myelitis, and connective tissue diseases.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review comprehensively analyzes the neurological complications associated with Sjögren's Syndrome (SS), focusing on peripheral neuropathy, central nervous system (CNS) involvement, cognitive dysfunction, and autonomic dysregulation. Eight studies, published between 2010 and 2024, were meticulously selected, encompassing a range of study designs, patient populations, and diagnostic methodologies. The findings highlight the substantial burden of neurological manifestations in SS, with peripheral neuropathy identified as the most prevalent complication, followed by cognitive impairment and CNS vasculitis. The review underscores the critical need for standardized diagnostic criteria and outcome measures to facilitate early detection and effective intervention. Although some studies report promising results regarding the efficacy of immunotherapy and other therapeutic approaches, the absence of randomized controlled trials (RCTs) significantly hampers the ability to establish definitive treatment guidelines. Additionally, this review highlights the importance of accounting for confounding factors, such as comorbid conditions, in understanding disease progression and treatment efficacy. It calls for further research to investigate innovative therapeutic options and develop personalized treatment plans tailored to the specific needs of SS patients with neurological complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.