ArticleCureus2025
Efficacy of Intravenous Lidocaine and Magnesium in the Management of Herpes Zoster Neuritis and Postherpetic Neuralgia: A Case Series.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesHerpes zoster is a common disease encountered in clinical practice. The neuropathic pain caused by herpes zoster can be severe enough to interfere with daily life in challenging cases. Although it is said that intervening as early as possible after the onset of the disease improves outcomes, there are some cases that are difficult to treat as immediate interventional therapy is not possible. While there are some reports on the efficacy of intravenous magnesium and lidocaine, we investigated the efficacy of intravenous magnesium and lidocaine in patients with herpes zoster neuritis and postherpetic neuralgia. Patient criteria: A total of 23 patients with herpes zoster neuritis and postherpetic neuralgia were included in the study. We included only cases in which immediate interventional therapy was not possible.
methodsThe treatment protocol was an intravenous infusion of a combination of 1.2 g of magnesium and 100 mg of lidocaine for one hour every week for four weeks (five times in total). Patients were assessed using the Numerical Rating Scale (NRS) for pain before and after the treatment at week zero and before the treatment at weeks one, two, three, and four.
resultsThere was a statistically significant difference between the median NRS before treatment at week zero and the median NRS before treatment at week one. Similarly, there was a statistically significant difference between the median NRS before treatment at week zero and the median NRS before treatment at weeks two, three, and four. In addition, the NRS tended to decrease as the number of treatments increased.
conclusionsIntravenous lidocaine and magnesium may be effective for herpes zoster neuritis and postherpetic neuralgia. It may be a treatment method for when immediate interventional therapy is not possible.
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