ArticleCureus2025
Antipsychotic Polypharmacy for Treatment Resistant Schizoaffective Disorder: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This case presents a male in his early 20s with schizoaffective disorder and cannabis use disorder presenting with treatment resistance demonstrated by inadequate control of psychotic symptoms despite multiple trials of antipsychotics. The patient was experiencing positive symptoms, including hyper-religiosity, hallucinations, mood lability, agitation, and aggression. The patient and next of kin were unable to provide consent for clozapine due to concerns for monitoring requirements. The patient continued paliperidone long-acting injectable (LAI) 234 milligrams (mg) every four weeks and divalproex 750 mg twice per day (BID) and was started on haloperidol with titration to 2 mg BID. Following the addition of a second antipsychotic agent, the patient exhibited marked improvement with reduced intensity of perceptual disturbances. This case underscores the potential benefits and challenges of antipsychotic polypharmacy in addressing residual psychosis and improving functional outcomes. We also provide an overview of available evidence for and against antipsychotic polypharmacy, defined as two or more antipsychotic medications used in a patient concurrently, as well as alternative non-antipsychotic agents for treatment-resistant schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.