Evidence map›Paper›PMID 40190822›Full record

ArticleResearch in pharmaceutical sciences2025

Development and evaluation of Sahasthara Thai medicine remedy in a film-forming spray for topical anti-inflammatory therapy.

Ninnart Intharit, Arunporn Itharat, Chadchom Choockong, Weerachai Pipatrattanaseree, Wichan Ketjinda, Neal M Davies, Raimar Löbenberg

Abstract read
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In one paragraph

Article in Research in pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ninnart IntharitDepartment of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand.
Arunporn ItharatDepartment of Applied Thai Traditional Medicine and Center of Excellence in Applied Thai Traditional Medicine Research (CEATMR), Faculty of Medicine, Thammasat University, Khlong Luang, Pathum Thani, 12120, Thailand.
Chadchom ChoockongDepartment of Applied Thai Traditional Medicine and Center of Excellence in Applied Thai Traditional Medicine Research (CEATMR), Faculty of Medicine, Thammasat University, Khlong Luang, Pathum Thani, 12120, Thailand.
Weerachai PipatrattanasereeRegional Medical Science Center 12 Songkhla, Department of Medical Sciences, Songkhla 90100, Thailand.
Wichan KetjindaDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkhla University, Songkhla 90112, Thailand.
Neal M DaviesFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2P5, Canada.
Raimar LöbenbergFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2P5, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: The study aimed to develop a localized topical anti-inflammatory treatment using a Thai medicinal herbal remedy called "Sahasthara," known for its anti-inflammatory properties, to create a film-forming spray (FFS). Experimental approach: This research evaluated and developed an FFS formulated with Sahasthara ethanolic extract (SHTe). Subsequently, the optimized formulation was investigated for Findings/Results: An optimized formulation (F12) was identified, consisting of 1% w/w SHTe and PVP K90, glycerol, PEG 400, sesame oil, a eutectic blend, and ethanol. This clear, smooth surface, yellowish film releases 42.37%, 38.67%, and 68.93% at 8 h, corresponding to a flux of 20.94, 1.92, and 26.32 µg/cm2/h of piperine, plumbagin, and β-asarone, respectively. F12 was determined to have a viscosity, drying time, and spray angle of 20 cps, 4.57 min, and 66.0 degrees. Conclusion and implications: SHTe FFS offers optimal spray ability, a high

Indexed as

Anti-inflammatoryDrug releaseFilm-forming spraySahastharaStability studyTopical drug

Identifiers

PMID40190822
PMCPMC11972029

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.