Evidence map›Paper›PMID 40190785›Full record

ArticlePain reports2025

Psychological and immunological associations with movement-evoked low back pain among older adults.

Riley Kahan, Arthur Woznowski-Vu, Janet L Huebner, Carl F Pieper, Adam P Goode, Steven Z George, Timothy H Wideman, Virginia Byers Kraus, Cathleen Colón-Emeric, Corey B Simon

Abstract read
In one paragraph

Article in Pain reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Rethinking Measurement of Movement-Evoked Pain with Digital Technology.medRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Riley KahanDepartment of Surgery, Duke University School of Medicine, Durham, NC, USA.
Arthur Woznowski-VuSchool of Physical & Occupational Therapy, McGill University, Montreal, QC, Canada.
Janet L HuebnerDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Carl F PieperCenter for Aging and Human Development, Duke University School of Medicine, Durham, NC, USA.
Adam P GoodeDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, USA.
Steven Z GeorgeDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, USA.
Timothy H WidemanSchool of Physical & Occupational Therapy, McGill University, Montreal, QC, Canada.
Virginia Byers KrausDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Cathleen Colón-EmericCenter for Aging and Human Development, Duke University School of Medicine, Durham, NC, USA.
Corey B SimonCenter for Aging and Human Development, Duke University School of Medicine, Durham, NC, USA.ORCID https://orcid.org/0000-0002-6121-9511

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI CATHLEEN S COLON-EMERIC, Susan Nicole Hastings · 2006 to 2026
$24.6M
Biomarkers to Advance Clinical Phenotypes of Low Back Pain (BACk)R01AR071440 · NIAMS · DUKE UNIVERSITY · PI Adam Goode · 2017 to 2026
$5.0M
Stress Reactivity and Low Back Pain in Older Adults: Influences on Disability (ReLOAD)K76AG074943 · NIA · DUKE UNIVERSITY · PI Corey Simon · 2022 to 2026
$1.0M
Mentoring in Musculoskeletal Pain PhenotypesK24AR079594 · NIAMS · DUKE UNIVERSITY · PI Adam Goode · 2022 to 2026
$927k
NIAMS NIH HHS K24 AR079594NIAMS NIH HHS R01 AR071440NIA NIH HHS K76 AG074943NIA NIH HHS P30 AG028716
6 · The paper itself

Abstract

Introduction: Low back pain (LBP) is a leading global factor in disability among older adults. Movement-evoked pain (MEP) is potentially an important mediator in the disability pathway but is predominantly tested in the laboratory. Objectives: We aimed to explore MEP in the natural environment ("daily" MEP) and its correlation with laboratory MEP, along with potential psychological and immunological influences. Method: Thirty-five older adults with persistent LBP attended a single laboratory session. Pain catastrophizing, pain-related fear of movement, and pain self-efficacy were measured by questionnaire. Resting inflammation and inflammatory reactivity to painful movement were evaluated using serum interleukin-6, tissue necrosis factor alpha, and C-reactive protein (CRP). Laboratory MEP was defined by aggregate pain intensity with a movement provocation test. Daily MEP was measured for the next 7 days using ecological momentary assessment. Results: Laboratory MEP was strongly correlated with daily MEP ( Conclusion: Preliminary indication is that laboratory and daily MEP may be proxy measures for one another, and that MEP is influenced by psychological and immunological factors. Future studies will aim to (1) validate findings among older adults with persistent LBP and (2) for clinical phenotyping, clarify complex relationships among psychological and immunological factors with disability pathway components like MEP.

Indexed as

CatastrophizingInflammationLow back painMovement-evokedOlder adultsReactivity

Identifiers

PMID40190785
PMCPMC11970892

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.